The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Korean Corni Fructus On treatment of Osteoporosis In Ovariectomized Rats

한국산 산수유가 난소적출로 유발된 흰쥐의 골다공증 치료효과에 미치는 영향

  • Joo, Seok-Joong (Department of Herbology, College of Oriental medicine, Daegu Hanny University.) ;
  • Park, Ji-Ha (Department of Herbology, College of Oriental medicine, Daegu Hanny University.) ;
  • Seo, Bu-Il (Department of Herbology, College of Oriental medicine, Daegu Hanny University.)
  • 주석중 (대구대학교 한의과대학 본초학교실) ;
  • 박지하 (대구대학교 한의과대학 본초학교실) ;
  • 서부일 (대구대학교 한의과대학 본초학교실)
  • Published : 2007.06.30
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Abstract

Objectives : The present study had been undertaken to investigate the effects of Korean Corni Fructus(KCF) on treatment of osteoporosis in ovariectomized rats. Method : In this experiment, the rats were ovariectomized. Rats were administered by KCF. The levels of bone mineral density, osteocalcin, ALP, calcium, phosphorus in serum, calcium, phosphorus, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured. Results : The levels of femoral and fibula-tibial bone mineral density were significantly increased in comparison with OVX group at 4, 8 weeks in KCF group. The levels of serum osteoclacin showed significant decrease in comparison with OVX group at 4, 8 weeks in KCF group. The levels of serum ALP showed significant decrease in comparison with OVX group at 4 week in KCF group. The levels of serum calcium showed significant increase in comparison with OVX group at 8 week in KCF group. The levels of urine calcium and phosphoruls showed significant decrease in comparison with OVX group in KCF group. The levels of femoral and fibula-tibial calcium didn't show significant changes in comparison with OVX group in KCF group. The levels of femoral and fibula-tibial phosphorus didn't show significant changes in comparison with OVX group in KCF group. The levels of femoral and fibula-tibial ash weight didn't show significant changes in comparison with OVX group in KCF group. The levels of body weight were significantly decreased in comparison with OVX group at 4, 8 weeks in KCF group. The levels of uterus weight were significantly increased in comparison with OVX group in KCF group. Conclusion : Reviewing these experimetal results, it appeared that KCF had efficacy on treatment of osteoporosis.

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