The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of a Mixture Ginseng Radix, Chaenomelis Fructus on the Mice Model of Alzheimer's Disease

인삼(人蔘), 목과(木瓜) 추출액이 Alzheimer성 치매의 병태(病態) 모델에 미치는 영향

  • Han, Sin-Hee (Dept. of Oriental Health Care, Joongbu University) ;
  • Kil, Gi-Jung (Dept. of Oriental Medicine Resources, Joongbu University)
  • 한신희 (중부대학교 한방건강관리학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Published : 2007.03.30
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Abstract

Objectives : This research was investigated the effect of the Ginseng Radix plus Chaenomelis Fructus on Alzheimer's disease. Methods : Specifically, the effects of the Ginseng Radix plus Chaenomelis Fructus extract on $IL-1{\beta}$, $TNF-{\alpha}$ of BV2 microglia cell line treated with lipopolysacchride. Results : The Ginseng Radix plus Chaenomclis Fructus extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by ${\beta}$ amyloid peptide. Conclusion: These results suggest that the Ginseng Radix plus Chaenomelis Fructus extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Ginseng Radix plus Chaenomelis Fructus extract for Alzheimer's disease is suggested for future research.

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