The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)
- Volume 20 Issue 1 Serial No. 32
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- Pages.130-144
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- 2007
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- 1738-6640(pISSN)
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- 2234-4020(eISSN)
The Effects of Jawoongo(紫雲膏) on UVB Damage to Skin And Photoaging
자운고(紫雲膏)가 자외선에 의한 피부손상 및 광노화(光老化)에 미치는 영향
- Published : 2007.04.25
Abstract
UV-irradiated skin shows acutely erythema, edema, pigmantation (sunbum) and chronically coarse wrinkling, roughness, dryness, laxity (photoaging). Jawoongo(紫雲膏, JW) is clinically useful external application and effective bum, sunburn, wound and symptom of dryness(燥症) in skin disease. In this experiment, we examined if JW could cure the UVB-mediated acute skin damages, inhibit UVB-mediated oxidative stress and inflammation of skin, and block the photoaging. In vivo test, we found that JW could effectively cure the UVB-mediated acute skin damages(erythema, edema, angiogenesis, hyperplasia, infiltration of lymphocytes) and inhibit expression of HSP70, CYP1A1 and p53. We also found that JW could repair destruction of collagen fiber and inhibit activation of MMP-9, and inhibit expression of