The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)
- Volume 20 Issue 1 Serial No. 32
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- Pages.27-37
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- 2007
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- 1738-6640(pISSN)
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- 2234-4020(eISSN)
Scutellaria baicalensis ethanol extracts inhibit IGF-II-induced HIF-1 ${\alpha}$ and VEGF expressions in HaCaT cells.
황금 에탄올 추출물이 IGF-II로 유도된 $HIF-1{\alpha}$ 와 VEGE 발현 억제에 미치는 영향
- Published : 2007.04.25
Abstract
Background and Objective : Psoriasis is a chronic skin disease characterized by angiogenesis. It has been reported that growth factor as vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-II are overexpressed in psoriatic epidermis. This stydy was carried out for whether SB extracts have an anti-angiogenic effect for angiogenic factor. Method : To investigate the inhibitory effect of VEGF expression by the SB extracts, we performed MTS assay, western blots using HaCaT cells. HaCaT cells were pretreated with SB extracts for 1 hour followed by treatment with IGF-II. Result : SB extracts significantly reduced IGF-II induced HIF-1