Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Water Extract of Flowers of Magnolia Denudata Inhibits LPS-induced Nitric Oxide and Pro-inflammatory Cytokines Production in Murine Peritoneal Macrophage by Inhibiting $NF-{\kappa}B$ Activation

LPS로 활성화된 복강 대식세포에서 신이 추출물의 염증성 사이토카인 및 NO 억제 효과

  • Kim, Do-Yun (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Jeong, Won-Seok (Department of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Hyoung-Chul (Department of Clinical laboratory, Wonkwang University Gwangju Medical Center) ;
  • Park, Sung-Joo (Department of Herbology, College of Oriental Medicine, Wonkwang University)
  • 김도윤 (원광대학교 한의과대학 본초학교실) ;
  • 정원석 (원광대학교 한의과대학 본초학교실) ;
  • 문형철 (원광대학교 부속 광주한방병원 침구학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실)
  • Published : 2007.08.25
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Abstract

Flowers of Magnolia denudata has been reported to possess a variety of pharmacological activities. In this study, we investigated the anti-inflammatory effects and mechanism of the water extract of Flowers of Magnolia denudata(MD) in lipopolysacchride (LPS)-mediated inflammatory mediators in murine peritoneal macrophages. MD itself does not have any toxic effects in murine peritoneal macrophages. MD inhibits LPS-induced nitric oxide (NO), tumor necrosis factor $(TNF)-{\alpha}$, IL-6 and IL-12 production in murine peritoneal macrophages. Furthermore, we have found that MD inhibited LPS-induced $NF-{\kappa}B$ but not c-Jun N-terminal kinase (JNK), p38 and extracellular signal-ragulated kinase (ERK) activation. These results suggested that MD inhibit LPS-induced production of $TNF-{\alpha}$, IL-6 and IL-12 via suppression of the $NF-{\kappa}B$ activation.

Keywords

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