법제 유황 경구투여가 간독성에 미치는 영향

Effect of Oral Administration of Processed Sulphur on Hepatotoxicity

  • 송인선 (이미지한의원) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 유화승 (대전대학교 한의과대학 동서암센터)
  • Song, In-Sun (Image Oriental Medical Clinic) ;
  • Youn, Dae-Hwan (Department of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, College of Oriental Medicine, Daejeon University)
  • 발행 : 2007.08.25

초록

This study was to evaluate the effects of oral administration of Processed Sulphur on Hepatotoxicity. Processed Sulphur was administered orally to rats for 28 days. We measured the body and liver weight index, heamtological and biomedical parameters. We also observed the histopathological changes of liver in rats. No significant differences in body weight, liver weight index, heamtological and biomedical parameters and histopathological changes of hepatocyte between control and Processed Sulphur fed group were found. Our data indicate that hepatotoxicity was not caused by oral medication of Processed Sulphur up to 60mg/200g/day for 28 days in rats. Therefore, Processed Sulphur appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) in rats is established at 60mg/200g/day. The data could provide satisfactory preclinical evidence of safety to launch clinical trial on standardized formulation of mineral extracts.

키워드

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