동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권4호
  • /
  • Pages.849-855
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  • 2007
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

비허온습만(脾虛蘊濕万)이 아토피 피부염 유발 NC/Nga 생쥐의 혈액내 면역 관련 인자에 미치는 영향

Effects of BHOSB on Various Immunological Factors Related to Pathogenesis of Atopic Dermatitis in DNCB Treated NC/Nga Mice

  • 박성희 (대전대학교 한의과대학 병리학교실) ;
  • 진미림 (대전대학교 한의과대학 병리학교실) ;
  • 구영선 (대전대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Park, Sung-Hee (Department of Pathology, College of Oriental medicine, Daejon University) ;
  • Jin, Mi-Rim (Department of Pathology, College of Oriental medicine, Daejon University) ;
  • Koo, Young-Sun (Department of Internal Medicine, College of Oriental medicine, Daejon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental medicine, Daejon University)
  • 발행 : 2007.08.25
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초록

Atopic dermatitis is an allergic inflammatory skin disease caused by aberrant and overreactive immune responses including overactivation of $T_H2$ immune responses, high levels of IgE as well as proinflammatory cytokines and chemokines. We examined whether BHOSB, a traditional herbal medicine, has modulatory effects on various immunological factors related to pathogenesis of atopic dermatitis in ONCB treated NC/Nga mice. Oral administration of BHOSB at the concentration of 10.8 mg/mouse/day significantly inhibited the production of IgE compared with control, and the levels of IgG2a and IgG2b, but not IgG1, were also significantly reduced. Production of IL-6 and TNF-a was greatly decreased. The results from flowcytometry of peripheral blood mononuclear cells indicated that the percentages of C03+C069+ cells and C04+ were significantly decreased by BHOSB. Theses results suggested that BHOSB has suppressive effects on aberrant and overreactive immunological activities in ONCB-induced dermatitis mice of NC/Nga.

키워드

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