Journal of Nutrition and Health

  • 제40권5호
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  • Pages.413-418
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  • 2007
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

만성적으로 알코올을 섭취한 쥐의 조직 내 Fatty Acid Ethyl Esters (FAEEs)와 지질과산화물 형성에 미치는 영향

Effect of Chronical Ethanol Ingestion on the Levels of Fatty Acid Ethyl Esters (FAEEs) and Lipid Peroxidation in Rat Tissues

  • 김민석 (경희대학교 생활과학대학 식품영양학과) ;
  • 김세나 (경희대학교 생활과학대학 식품영양학과) ;
  • 박현서 (경희대학교 생활과학대학 식품영양학과)
  • Kim, Min-Seok (Department of Food and Nutrition, Kyung-Hee University) ;
  • Kim, Se-Na (Department of Food and Nutrition, Kyung-Hee University) ;
  • Park, Hyun-Suh (Department of Food and Nutrition, Kyung-Hee University)
  • 발행 : 2007.07.31
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초록

The present study was designed to observe the effect of chronically ingested ethanol on the level of fatty acid ethyl esters (FAEEs), which is a non-oxidative metabolite of ethanol metabolism in tissues, and its correlation to the status of oxidative stress in rats. Forty male Sprague Dawley rats weighing 145 - 155 g were divided into 2 groups, Control and EtOH. All rats were fed Lieber-DeCarli liquid diet for 4 weeks by pair-feeding. An isocaloric maltose dextrin was added in replace of 50 g ethanol (36%kcal) in the control diet. Chronically ingested ethanol significantly increased the content of FAEEs in pancreas and liver, but not in brain. The level of 2-thiobarbituric acid reactive substances (TBARS) was significantly increased, but ${\alpha}-tocopherol$ level was significantly decreased in pancreas and liver. However, the levels of TBARS and ${\alpha}-tocopherol$ in brain were not significantly affected by ethanol ingestion. Therefore, chronically ingested ethanol might cause tissue damage by increasing the levels of FAEEs and TBARS and dissipating more ${\alpha}-tocopherol$ in tissues.

키워드

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