대한한의학회지 (The Journal of Korean Medicine)
- 제28권3호통권71호
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- Pages.273-288
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
정전가미이진탕(正傳加味二陳湯)이 Dibutyltin Dichloride(DBTC)로 유발된 흰쥐의 췌장염에 미치는 영향
The effects of Jengjengamiyjin-tang on Pancreatitis induced by DBTC in Mouse
- 최흥민 (동국대학교 한의과대학 비계내과학 교실) ;
- 김학재 (동국대학교 한의과대학 비계내과학 교실) ;
- 한이수 (동국대학교 한의과대학 비계내과학 교실) ;
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임성우
(동국대학교 한의과대학 비계내과학 교실)
- Choi, Heung-Min (Department of Oriental Medicine, College of Korean Medicine, Dongguk University) ;
- Kim, Hak-Jae (Department of Oriental Medicine, College of Korean Medicine, Dongguk University) ;
- Han, Yi-Soo (Department of Oriental Medicine, College of Korean Medicine, Dongguk University) ;
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Lim, Seong-Woo
(Department of Oriental Medicine, College of Korean Medicine, Dongguk University)
- 발행 : 2007.09.30
초록
Objectives : We examined the effect of Jengjengamiyjin-tang, a traditional herbal formula, on the experimental pancreatitis induced by Dibutyltin Dichloride(DBTC). Methods : 15 mice were divided into 3 groups; the normal group and the control group which were administered water only after pancreatitis elicitation and the test group which were administered Jengjengamiyjin-tang for 7 days after pancreatitis elicitation. Results : In the activities of amylase, lipase and alkaline phosphatase in serum, the test group showed significant decrease compared with the control group after 21 days. In the common morphology and histochemical study, various injuries by hemorrhagic erosion were observed in the control group, while they were significantly decreased in the test group. In the immunohistochemical study, the manifestation of COX-1, 2, HSP27, HSP70, MAC387, Ki-67 decreased significantly in the 14th day in the test group, however, they increased in the 21st day more than the control group(p<0.05). Conclusion : According to the above results, it is supposed that Jengjengamiyjin-tang has anti-inflammatory effect on the experimentally induced pancreatitis and may be applicable to pancreatitis especially in the acute stage.