Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp.

  • Zhang, Dahai (Department of Chemistry, Pukyong National University) ;
  • Noviendri, Dedi (Department of Chemistry, Pukyong National University) ;
  • Nursid, Muhammad (Department of Chemistry, Pukyong National University) ;
  • Yang, Xiu-Dong (Department of Chemistry, Pukyong National University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Published : 2007.09.30
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Abstract

Dioxopiperazine alkaloids, 12R,13S-dihydroxyfumitremorgin C (1), fumitremorgin C (2), and brevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolute stereostructures of compounds 1 - 3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1 - 3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC (minimum inhibitory concentration) values of compounds 1 - 3 were 125 ${\mu}g/mL$ for all strains.

Keywords

References

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