Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antinociceptive and antidiarrhoeal activities of Bruguiera gymnorrhiza

  • Ahmed, F (Pharmacy Discipline, Khulna University) ;
  • Shahid, IZ (Pharmacy Discipline, Khulna University) ;
  • Gain, NC (Pharmacy Discipline, Khulna University) ;
  • Reza, MSH (Pharmacy Discipline, Khulna University) ;
  • Sadhu, SK (Pharmacy Discipline, Khulna University)
  • Published : 2007.09.30
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Abstract

The methanol extract of leaves of Bruguiera gymnorrhiza (L.) Lam. (Rhizophoraceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant inhibition in acetic acid-induced writhing in mice at dose of 250 and 500 mg/kg body weight (P < 0.001), comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (P < 0.001). When tested for its antidiarrhoeal effects on castor oil-induced diarrhea in mice, it increased mean latent period (P < 0.02) and decreased the frequency of defecation (P < 0.01) significantly at the dose of 500 mg/kg body weight, comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.

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References

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