Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 13 Issue 1 Serial No. 19
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- Pages.161-164
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- 2007
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- 1229-3377(pISSN)
Acute Toxicity Study on SsangHwaTang in Mice
쌍화탕 급성독성에 대한 안전성 연구
- Park, Dae-Hun (Korea Institute of Oriental Medicine) ;
- Park, Kyeong-Soo (JaSeng Hospital Oriental Medicine) ;
- Do, Kyoung-Tag (Korea Institute of Oriental Medicine) ;
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Shin, Hyun-Kyoo
(Korea Institute of Oriental Medicine)
;
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Ma, Jin-Yeul
(Korea Institute of Oriental Medicine)
- Published : 2007.04.30
Abstract
SsangHwaTang has been traditionally prescribed a medicine as a restorative. In this study, We investigated the acute toxicity about water-extracted SsangHwaTang. Twenty-five mice completed 14 days of oral SsangHwaTang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. And then we observed survival rates, general toxicity, change of body weight, and autopsy. Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). In conclusion, LD50 of SsangHwaTang was over 5000mg/kg and it is very safe to ICR mice.