The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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The Effect of JokyungSan on the Ovarian Functions and Differential Gene Expression of Caspase-3, MAPK and MPG in Female Mice

조경산(調經散)이 자성 생쥐의 생식능력과 Caspase-3, MAPK 및 MPG 유전자 발현에 미치는 영향

  • Lee, Hyung-Gon (Dept. of OB & GY, Oriental Medicine, Daeguhaany University) ;
  • Baek, Seung-Hee (Odri women's Traditional Korean Medical Clinic) ;
  • Kim, En-Ha (Dept. of Original text and Medical history, Oriental Medicine, Daeguhaany University) ;
  • Kim, Dong-Chul (Dept. of OB & GY, Oriental Medicine, Daeguhaany University)
  • 이형곤 (대구한의대학교 한의과대학 부인과교실) ;
  • 백승희 (오드리 여성한의원) ;
  • 김은하 (대구한의대학교 한의과대학 원전의사학교실) ;
  • 김동철 (대구한의대학교 한의과대학 부인과교실)
  • Published : 2007.05.29
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Abstract

Purpose : These experiments were undertaken to evaluate the effect of adminis tration of JokyungSan on ovarian functions and differential gene expressions related cell viabilities caspase-3, MAPK and MPG in female mice. Methods : We administered the JokyungSan to 6-week-old female ICR mice for 4, 8, or 12 days. The female mice were injected PMSG and hCG for ovarian hyperstimulation. We chose the caspase-3 for cell apoptosis, MAPK and MPG genes for cell viability and DNA repair. To compare the differences, we set a control group treated with plain water at the same volume by the same way. Results : In case of 4-day administration of JokyungSan, the mean number of total ovulated oocytes and the number of morphologically normal oocytes increased significantly compared to a control group. The administration of JokyungSan, were beneficial effect of embryonic development in preimplantation period and play a role of prevention of cell apoptosis and DNA damages and also increased cell proliferation resulted in ovarian functions. Conclusion : From our results suggested that the medication of JokyungSan has beneficial effect on reproductive functions of female mice via prevention of cell apoptosis and DNA damaging and promotion of cell proliferation.

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