한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제24권3호
  • /
  • Pages.400-405
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  • 2007
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

헛개나무추출액 및 생약성분의 혼용이 사염화탄소 투여로 유발된 흰쥐의 급성 간 및 신장손상의 회복에 미치는 영향

The Therapeutic Effect of Hovenia dulcis Thunberg Extracts and 6 Types of Herbal Extracts on $CCl_4-Induced$ Acute Liver and Kidney Damages in Rats

  • 임미경 (경북대학교 생활과학대학) ;
  • 김주완 (경북대학교 수의과대학) ;
  • 김지은 (대구대학교 생명공학과) ;
  • 김홍태 (부산광역시 보건환경연구원) ;
  • 정상주 (경북대학교 수의과대학) ;
  • 강미영 (경북대학교 생활과학대학) ;
  • 이근우 (경북대학교 수의과대학)
  • Lim, Mee-Kyoung (Department of Food Science and Nutrition, School of Human Ecology, Kyungpook National University) ;
  • Kim, Joo-Wan (Department of Internal Medicine, School of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Ji-Eun (Department of Biotechnology, Daegu University) ;
  • Kim, Hong-Tae (Busan Metropolitan City Institute of Health and Environment) ;
  • Jung, Sang-Ju (Department of Internal Medicine, School of Veterinary Medicine, Kyungpook National University) ;
  • Kang, Mi-Young (Department of Food Science and Nutrition, School of Human Ecology, Kyungpook National University) ;
  • Lee, Keun-Woo (Department of Internal Medicine, School of Veterinary Medicine, Kyungpook National University)
  • 발행 : 2007.09.30
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초록

This study was performed to investigate the therapeutic effects of Hovenia dulcis Thunberg (HDT) and HDTmix extracts on the biochemical analysis, histopathology and histomorphometry of liver and kidney in carbon tetrachloride $(CCl_4)$ administrated rats. Extract was prepared by autoclave ($121^{\circ}C$, 15 psi, 3 hours) and filtered with nylon cloth and filter paper then freezing dried. In blood chemistry analysis, HDTmix group, aspartate aminotransferase and alanine aminotransferase were significantly (p<0.01) decreased compared to the $CCl_4$ group, on 3rd day, respectively. In histologic and histomorphometry analysis, the $CCl_4-related$ hepatopathies and nephropathies were dramatically decreased (3rd, 5th day), and well corresponded to the histopathological changes significantly (p<0.01) decreases of degenerative regions, degenerative cells and glomeruli were detected in liver and kidney with significantly decreases of $CCl_4$ group. HDTmix group, quite similar effects on the liver and kidney were observed compared to that of HDT extracts group but more favorable efficacies were detected especially HDTmix also inhibit the hepatopathies (1 day), in which HDT extract does not showed any inhibit effects.

키워드

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