Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effect of Scutellaria Baicalensis Georgi. Extract on Cisplatin-Induced Acute Renal Failure in Rabbits

토끼에서 cisplatin에 의해 유도된 급성 신부전시 황금(黃芩; Scutellaria Baicalensis Georgi.) 추출물의 효과

  • Kim, Soo-Chang (Department of Animal Science and Resources Technology, Jinju National University) ;
  • Song, Yeong-Min (Department of Animal Science and Resources Technology, Jinju National University) ;
  • Lee, Sung-Dae (The United Graduate School of Agricultural Science, Kagoshima University) ;
  • Song, Seung-Hee (Department of Pet Management, Changwon College) ;
  • Koh, Phil-Ok (College of Veterinary Mdicine and Institute of Animal Medicine, GyeongSang National University) ;
  • Kim, Jong-Su (College of Veterinary Mdicine and Institute of Animal Medicine, GyeongSang National University) ;
  • Kim, Chung-Hui (Department of Animal Science and Resources Technology, Jinju National University) ;
  • Kang, Chung-Boo (College of Veterinary Mdicine and Institute of Animal Medicien, GyeongSang National University)
  • 김수창 (진주산업대학교 동물생명과학과, 동물소재공학과) ;
  • 송영민 (진주산업대학교 동물생명과학과, 동물소재공학과) ;
  • 이성대 (가고시마대학교 축산학부) ;
  • 송승희 (창원전문대학 애완동물관리과) ;
  • 고필옥 (경상대학교 수의과대학, 동물의학연구소) ;
  • 김종수 (경상대학교 수의과대학, 동물의학연구소) ;
  • 김충희 (진주산업대학교 동물생명과학과, 동물소재공학과) ;
  • Published : 2007.09.30
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Abstract

Scutellaria baicalensis Georgi. (SBGE) is known to be antioxidant effect. In addition of the effects, we further investigated the SBGE on the antioxidant effect on a renal cortical slices cell and kidney protecting effects. The results were as follows. 1 When renal cortical slices separated from a rabbit's kidney were treated with 1mM tert-Butylhydroperoxide (t-BHP) in the presence of SBGE. SBGE significant prevented t-BHP induced increase in lactate dehydrogenase (LDH) release and lipid peroxidation. 2. When renal cortical slices separated from a rabbit's kidney were treated with oxidant $300{\mu}M$ cisplatin in the presence of SBGE. SBGE significant prevented cisplatin-induced increase in LDH release and lipid peroxidation. 3. Pretreatment with 0.1g/kg SBGE for seven day and treatment with 5 mg/kg cisplatin by the intraperitoneal injection The results were that the pretreatment group with SBGE showed a significant decrease in lipid peroxidation, increase in clearance rate of blood urea nitrogen (BUN) and creatinine in the kidney than the administering single agent group of cisplatin. and pretreatment group with SBGE showed intact microvillus of proximal tubule and no contraction of rumen, it was a similar result with normal group. With the results SBGE showed to be highly effective on antioxidant effect and cellular protection activity against cisplatin that was a toxic agent on a kidney. Therefore, SBGE is considered to have protective effective on a disordered kidney or kidney diseases such as nephritis or renal failure that cause tissue damages in a kidney.

Keywords

References

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