한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제24권3호
  • /
  • Pages.379-383
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  • 2007
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Rat에서 carboxymethylcellulose, chondroitin 및 carboxymethylchitosan의 복강유착방지 효과의 비교

Comparative Effect of Carboxymethylcellulose, Chondroitin, and Carboxymethylchitosan on Preventing Intraperitoneal Adhesion Formation in Rats

  • 권영삼 (위스콘신-매디슨 대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학)
  • Kwon, Young-Sam (School of Veterinary Medicine, University of Wisconsin-Madison) ;
  • Jang, Kwang-Ho (College of Veterinary Medicine, Kyungpook National University)
  • 발행 : 2007.09.30
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초록

This study was performed to compare the effects of carboxymethylcellulose (CMCE), chondroitin sulfate (Chondron), and carboxymethylchitosan (CMCH) on preventing intraperitoneal adhesion. As a result, the tensile strength of adhesions formed between the parietal peritoneum and the ileal serosa was significantly decreased in the groups of three different kinds of anti-adhesive agents. The distance of adhesion site was slightly increased in the treatment groups comparing control group. In the CMCH group, the inflammatory cell infiltration, collagen hyperplasia, and neovascularization were significantly lower than those of control group. It was observed that the damage at intestinal serosa was significantly decreased in the chondron and CMCH groups comparing control group. Therefore CMCH may be useful as a anti-adhesive agent in the prevention of intraperitoneal adhesion in rats.

키워드

참고문헌

  1. Al-Chalabi HA, Otubo JA. Value of a single intraperitoneal dose of heparin in prevention of adhesion formation: an experimental evaluation in rats. Int J Fertil. 1987; 32: 332335
  2. Badawy SZ, Baggish MS, ElBakry MM, Baltoyannis P. Evaluation of tissue healing and adhesion formation after an intraabdominal amniotic membrane graft in the rat. J Reprod Med. 1989; 34: 198-202
  3. Blauer KL, Collins RL. The effect of intraperitoneal progesterone on postoperative adhesion formation in rabbits. Fertil Steril. 1988; 49: 144-149 https://doi.org/10.1016/S0015-0282(16)59666-6
  4. Bothin C, Midtvedt T, Perbeck L. Orally delivered antibiotics which lower bacterial numbers decrease experimental intraabdominal adhesions. Langenbecks Arch Surg. 2003; 388: 112-115
  5. Boyers SP, Diamond MP, DeChemey AH. Reduction of postoperative pelvic adhesions in the rabbit with Gore-Tex surgical membrane. Fertil Steril. 1988; 49: 1066-1070 https://doi.org/10.1016/S0015-0282(16)59962-2
  6. DeChemey AH, diZerega GS. Clinical problem of intraperitoneal postsurgical adhesion formation foIlowing general surgery and the use of adhesion prevention barriers. Surg Clin North Am. 1997; 77: 671-688 https://doi.org/10.1016/S0039-6109(05)70574-0
  7. Elkins TE, Ling FW, Ahokas RA, AbdeIla TN, Homsey CA, Malinak LR. Adhesion prevention by solutions of sodium carboxymethylceIlulose in the rat. II. Fertil Steril. 1984; 41: 929-932 https://doi.org/10.1016/S0015-0282(16)47910-0
  8. EIIis H, Harrison W, Hugh TB. The healing of peritoneum under normal and pathological conditions. Br J Surg. 1965; 52: 471-476 https://doi.org/10.1002/bjs.1800520616
  9. Falk K, Bjorquist P, Falk P, Hedgren M, Ivarsson ML, Lanne B, Panfilov O, Holmdahl L. Antifibrinolytic proCPU is present in the peritoneal cavity during surgery. Scand J Clin Lab Invest. 2003; 63: 287-296 https://doi.org/10.1080/00365510310001726
  10. Fevang BT, Fevang J, Lie SA, Soreide O, Svanes K, Viste A. Long-term prognosis after operation for adhesive small bowel obstruction. Ann Surg. 2004; 240: 193-201 https://doi.org/10.1097/01.sla.0000132988.50122.de
  11. Harris ES, Morgan RF, Rodeheaver GT. Analysis of the kinetics of peritoneal adhesion formation in the rat and evaluation of potential antiadhesive agents. Surgery. 1995; 117: 663-669 https://doi.org/10.1016/S0039-6060(95)80010-7
  12. Holtz G. Current use of anciIlary modalities for adhesion prevention. Fertil Steril. 1985; 44: 174-176 https://doi.org/10.1016/S0015-0282(16)48730-3
  13. Jang KH, Kwon YS, Kim JE, Kwon, EJ, Oh TH, Lee KW, Jang IH. Effect of carboxymethyl chitosan on postoperative intraperitoneal adhesion formation in the rat. Korean J Vet Res. 2000; 40: 635-643
  14. Kennedy R, Costain DJ, McAlister VC, Lee TD. Prevention of experimental postoperative peritoneal adhesions by N,O-carboxymethyl chitosan. Surgery. 1996; 120: 866-870 https://doi.org/10.1016/S0039-6060(96)80096-1
  15. Kwon YS, Jang HS, Jeong JH, Bae JS, Rhee JW, Kang HS, Yang JH, Li WX, Jang KH. Effect of high concentration of carboxymethyl chitosan on preventing formation of peritoneal adhesion in rats. Korean J Vet Res. 2003; 43: 151-156
  16. Larsson B, Lalos O, Marsk L, Tronstad SE, Bygdeman M, Pehrson S, Joelsson I. Effect of intraperitoneal instillation of 32% dextran 70 on postoperative adhesion formation after tubal surgery. Acta Obstet Gynecol Scand. 1985; 64: 437-441 https://doi.org/10.3109/00016348509155163
  17. Menzies D. Peritoneal adhesions. Incidence, cause, and prevention. Surg Annu. 1992; 24: 27-45
  18. Milligan DW, Raftery AT. Observations on the pathogenesis of peritoneal adhesions: a light and electron microscopical study. Br J Surg. 1974; 61: 274-280 https://doi.org/10.1002/bjs.1800610406
  19. Moll HD, Wolfe DF, Schumacher J, Wright JC. Evaluation of sodium carboxymethyIcellulose for prevention of adhesions after uterine trauma in ewes. Am J Vet Res. 1992; 53: 14541456
  20. Ray NF, Larsen JW Jr, Stillman RJ, Jacobs RJ. Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988. Surg Gynecol Obstet. 1993; 176: 271-276
  21. Reddy S, Santanam N, Reddy PP, Rock JA, Murphy AA, Parthasarathy S. Interaction of Interceed oxidized regenerated cellulose with macrophages: a potential mechanism by which Interceed may prevent adhesions. Am J Obstet Gynecol 1997; 177: 1315-1320 https://doi.org/10.1016/S0002-9378(97)70070-X
  22. Replogle RL, Johnson R, Gross RE. Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. Ann Surg. 1966; 163: 580-588 https://doi.org/10.1097/00000658-196604000-00011
  23. Sawada T, Hasegawa K, Tsukada K, Kawakami S. Adhesion preventive effect of hyaluronic acid after intraperitoneal surgery in mice. Hum Reprod. 1999; 14: 1470-1472 https://doi.org/10.1093/humrep/14.6.1470
  24. Siegler AM, Kontopoulos V, Wang CF. Prevention of postoperative adhesions in rabbits with ibuprofen, a nonsteroidal anti-inflammatory agent. Fertil Steril. 1980; 34: 46-49 https://doi.org/10.1016/S0015-0282(16)44838-7
  25. Swolin K. The effect of a massive intraperitoneal dose of a glucocorticoid on the formation of postoperative adhesions. Clinical studies using laparoscopy in patients operated on for extrauterine pregnancy. Acta Obstet Gynecol Scand. 1967; 46: 204-218
  26. Thaler K, Mack JA, Berho M, Grotendorst G, Wexner SD, Abramson SR. Coincidence ofconnective tissue growth factor expression with fibrosis and angiogenesis in postoperative peritoneal adhesion formation. Eur Surg Res. 2005; 37: 235241 https://doi.org/10.1159/000087869
  27. Tran HS, Chrzanowski FA Jr, Puc MM, Patel NG, Geldziler B, Malli D, Ramsamooj R, Hewitt CW, DelRossi AJ. An in vivo evaluation of a chondroitin sulfate solution to prevent postoperative intraperitoneal adhesion formation. J Surg Res. 2000; 88: 78-87 https://doi.org/10.1006/jsre.1999.5714
  28. Ueno H, Yamada H, Tanaka I, Kaba N, Matsuura M, Okumura M, Kadosawa T, Fujinaga T. Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials. 1999; 20: 1407-1414 https://doi.org/10.1016/S0142-9612(99)00046-0