Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

The Influence of Eye Movement for Acquiring BOLD Signal in V1 : A Study of Simultaneous Measurement of EOG and fMRI

  • Chung, Jun-Young (Neuroscience Research Institute, Gachon University of Medicine and Science) ;
  • Yoon, Hyo-Woon (Neuroscience Research Institute, Gachon University of Medicine and Science) ;
  • Kim, Young-Bo (Neuroscience Research Institute, Gachon University of Medicine and Science) ;
  • Park, Hyun-Wook (Department of Electrical Engineering, Korea Advanced Institute of Science and Technology)
  • Published : 2007.08.30
Download PDF
⟨ Previous Next ⟩

Abstract

We have measured EOG and fMRI simultaneously to investigate whether eye movement (blinking mechanism) might influence functional magnetic resonance imaging (fMRI) signal response in the primary visual cortex. $T2^*-weighted$ Echo-Planar Imaging (EPI) with concurrent electrooculogram (EOG) was acquired in four subjects while they viewed a fixation point and a checkerboard with a flickering rate of 8Hz. With the help of EOG information we divided the experimental blocks into two different conditions: fixation and moving eye. We have compared the fMRI data of these two conditions. Our results have shown that there is no difference between these two conditions. This might suggest that eye blinking does not affect BOLD signal changes in the primary visual cortex. This means further that eye blinking can be ignored in data processing.

Keywords

References

  1. S. Ogawa, T.M. Lee, A.R. Kay, and D.W. Tank et al., 'Brain magnetic resonance imaging with contrast dependent on blood oxygenation,' in Proc. Natl. Acad. Sci., 1990, vol. 87, no. 24, pp.9868-9872
  2. P.A. Bandettini, E.C. Wong, R.S. Hinks, R.S. Tikofsky, and J.S. Hyde, 'Time course EPI of human brain function during task activation,' Magn. Reson. Med., vol. 25, no. 2, pp.390-397, 1992 https://doi.org/10.1002/mrm.1910250220
  3. T. Ernst and J. Hennig, 'Observation of a fast response in functional MR,' Magn. Reson. Med., vol. 32, no. 1, pp.146-149, 1994 https://doi.org/10.1002/mrm.1910320122
  4. R.S. Menon, S. Ogawa, X. Hu, J.P. Strupp, P. Anderson, and K. Ugurbil, 'BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals,' Magn. Reson. Med., vol. 33, no. 3, pp.453-459, 1995 https://doi.org/10.1002/mrm.1910330323
  5. J.R. Tregellas, J.L. Tanabe, D.E. Miller, and R. Freedman, 'Monitoring eye movements during fMRI tasks with echo planar images,' Hum. Brain Mapp., vol. 17, no. 4, pp.237-243, 2002 https://doi.org/10.1002/hbm.10070
  6. P. Freitag, M.W. Greenlee, T. Lacina, K. Scheffler, and E.W. Radu, 'Effect of eye movements on the magnitude of functional magnetic resonance imaging responses in extrastriate cortex during visual motion perception,' Exp. Brain Res., vol. 119, no. 4, pp.409-414, 1998 https://doi.org/10.1007/s002210050356
  7. K. Tsubota, K.K. Kwong, T.Y. Lee, J. Nakamura, and H.M. Cheng, 'Functional MRI of brain activation by eye blinking,' Exp. Eye Res., vol. 69, no. 1, pp.1-7, 1999 https://doi.org/10.1006/exer.1999.0660
  8. P.J. Allen, G. Polizzi, K. Krakow, D.R. Fish, and L. Lemieux, 'Identification of EEG events in the MR scanner: the problem of pulse artifact and a method for its subtraction,' Neuroimage, vol. 8, no.3, pp.229-239, 1998 https://doi.org/10.1006/nimg.1998.0361
  9. F. Kruggel, C.J. Wiggins, C.S. Herrmann, and D.Y. von Cramon, 'Recording of the event-related potentials during functional MRI at 3.0 Tesla field strength,' Magn. Reson. Med., vol. 44, no. 2, pp.277-282, 2000 https://doi.org/10.1002/1522-2594(200008)44:2<277::AID-MRM15>3.0.CO;2-X
  10. P.J. Allen, O. Josephs, and R. Turner, 'A method for removing imaging artifact from continuous EEG recorded during functional MRI,' Neuroimage, vol. 12, no. 2, pp.230-239, 2000 https://doi.org/10.1006/nimg.2000.0599
  11. L. Muckli, N. Kriegeskorte, H. Lanfermann, F.E. Zanella, W. Singer, and R. Goebel, 'Apparent motion: event-related functional magnetic resonance imaging of perceptual switches and States,' J. Neurosci., vol. 22, RC219, pp.1-5, 2002
  12. J. Talairach and P. Tournoux, Co-Planar Stereotaxic Atlas of the Human Brain, New York, Thieme Medical Publishers, 1988
  13. G.M. Boynton, S.A. Engel, G.H. Glover, and D.J. Heeger, 'Linear systems analysis of functional magnetic resonance imaging in human V1,' J. Neurosci., vol. 16, no. 13, pp.4207-4221, 1996 https://doi.org/10.1523/JNEUROSCI.16-13-04207.1996
  14. H. Kimming, M.W. Greenlee, F. Huethe, and T. Mergner, 'MR-Eyetracker: a new method for eye movement recording in functional magnetic resonance imaging,' Exp. Brain Res., vol. 126, no. 3, pp.443-449, 1999 https://doi.org/10.1007/s002210050751
  15. M.S. Beauchamp, 'Detection of eye movements from fMRI data,' Magn. Reson. Med., vol. 49, no. 2, pp.376-380, 2003 https://doi.org/10.1002/mrm.10345