대한의생명과학회지 (Biomedical Science Letters)
- 제13권3호
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- Pages.175-182
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
In vitro Retention of Antimicrobial Activity of Ciprofloxacin-incorporated Central Venous Catheters
- Jeon, Sung-Min (Department of Biology, Sangmyung University) ;
- Kim, Mal-Nam (Department of Biology, Sangmyung University)
- 발행 : 2007.09.30
초록
In vitro ciprofloxacin (CFX)-release study and bioassay using microorganisms were performed to estimate the retention of the antimicrobial activity of the CFX-incorporated central venous catheters (CFX-CVCs). The release experiments were carried out under the optional CFX-release conditions to mimic the in vivo environment. The release of CFX experienced an initial burst followed by a slow and steady matrix-diffusion controlled release. The 1.0CP (polyurethane catheter containing 1.0% (w/w) of CFX) under dynamic condition showed a near zero-order CFX release profile, which is beneficial for the long-tenn antimicrobial activity. The modified Kirby-Bauer method was performed employing S. aureus and E. coli to evaluate the retention of antimicrobial activity of the catheters retrieved from the release experiments. The 1.0CP showed the long-term antimicrobial activity (
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