Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Validity of Expired Carbon Monoxide and Urine Cotinine Using Dipstick Method to Assess Smoking Status

호기 중 일산화탄소와 소변 코티닌 검사의 흡연상태 타당도 분석

  • Park, Su-San (School of Public Health and Institute of Health and Environment, Seoul National University) ;
  • Lee, Ju-Yul (Department of Health Administration, Namseoul University) ;
  • Cho, Sung-Il (School of Public Health and Institute of Health and Environment, Seoul National University)
  • 박수잔 (서울대학교 보건대학원 및 보건환경 연구소) ;
  • 이주열 (남서울대학교 보건행정학과) ;
  • 조성일 (서울대학교 보건대학원 및 보건환경 연구소)
  • Published : 2007.07.31
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Abstract

Objectives : We investigated the validity of the dipstick method (Mossman Associates Inc. USA) and the expired CO method to distinguish between smokers and non-smokers. We also elucidated the related factors of the two methods. Methods : This study included 244 smokers and 50 ex-smokers, recruited from smoking cessation clinics at 4 local public health centers, who had quit for over 4 weeks. We calculated the sensitivity, specificity and Kappa coefficient of each method for validity. We obtained ROC curve, predictive value and agreement to determine the cutoff of expired air CO method. Finally, we elucidated the related factors and compared their effect powers using the standardized regression coefficient. Results : The dipstick method showed a sensitivity of 92.6%, specificity of 96.0% and Kappa coefficient of 0.79. The best cutoff value to distinguish smokers was 5-6ppm. At 5 ppm, the expired CO method showed a sensitivity of 94.3%, specificity of 82.0% and Kappa coefficient of 0.73. And at 6 ppm, sensitivity, specificity and Kappa coefficient were 88.5%, 86.0% and 0.64, respectively. Therefore, the dipstick method had higher sensitivity and specificity than the expired CO method. The dipstick and expired CO methods were significantly increased with increasing smoking amount. With longer time since the last smoking, expired CO showed a rapid decrease after 4 hours, whereas the dipstick method showed relatively stable levels for more than 4 hours. Conclusions : The dipstick and expired CO methods were both good indicators for assessing smoking status. However, the former showed higher sensitivity and specificity and stable levels over longer hours after smoking, compared to the expired CO method.

Keywords

References

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