The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Experimental Research on the Effect of Haeyeol-tang

해열탕(解熱湯)의 항염증(抗炎症), 항산화(抗酸化), 항노화(抗老化) 작용(作用)에 대한 실험적(實驗的) 연구(硏究)

  • Chu, Cheng-Kang (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Jin-Ju (Dept. of Pharmacology, College of Pharmacy, Kyung Hee University) ;
  • Roh, Young-Lae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Sung-Hun (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Seung-Yeon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Hee-Jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Sung-Ki (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University)
  • 곡정강 (경희대학교 약학대학 약리학교실) ;
  • 김진주 (경희대학교 한의과대학 폐계내과학 교실) ;
  • 노영래 (경희대학교 약학대학 약리학교실) ;
  • 이성헌 (경희대학교 약학대학 약리학교실) ;
  • 정승연 (경희대학교 약학대학 약리학교실) ;
  • 정희재 (경희대학교 약학대학 약리학교실) ;
  • 정승기 (경희대학교 약학대학 약리학교실)
  • Published : 2007.12.30
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Abstract

Objectives : The purpose of this study was to examine the effect of Haeyeol-tang on infectious disease of respiratory system. Methods : Haeyeol-tang was used by cold storage after dilution with 1, 10 and $100{\mu}g/ml$ of PBS, from dried material as extracted material with extraction with 50% ethanol. Statistical significance was examined through measuring TNF-$\alpha$, RT-PCR, DPPH, nitric oxide(NO), and MTT of Raw264.7 cells activated with LPS. Results : For the toxicity experiment of Haeyeol-tang, almost no toxicity was shown on cells in the concentration ranges of 1, 10 and $100{\mu}g/ml$. For the effect of NO production, Haeyeol-tang showed significant (p<0.001) decrease of NO production, according to its concentration. For the effect on the eliminating activity of DPPH radical, Haeyeol-tang showed increasing tendency of eliminating activity of DPPH radical, according to its concentration. For the effect on revelation of NOS2 enzyme, Haeyeol-tang showed inhibiting tendency against the revelation of NOS2, according to its concentration. For the effect on the TNF-$\alpha$ production, Haeyeol-tang showed significant (p<0.001) decrease of TNF-$\alpha$ production. Conclusions : This result means that Haeyeol-tang is effective for anti-inflammation, as well as excellent effect for anti-oxidation and anti-aging.

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