The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Research on Effects of Cordyceps Sinensis in Arthritis Synovial Cells

동충하초 추출물이 관절염 Synovial Cell에 미치는 영향

  • Kim, Chan-Ku (Dept. of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Roh, Seong-Soo (Dept. of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Seo, Young-Bae (Dept. of Herbology, College of Oriental Medicine, Daejeon University)
  • 김찬구 (대전대학교 한의과대학) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 서영배 (대전대학교 한의과대학)
  • Published : 2007.09.28
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Abstract

Objectives : This study was carried out to know the effect of Cordyceps sinensis(CS) on the immune inflammatory responses of athritis and function. Methodes : To analyse immunomodulatory effects of CS, cytotoxicity and inhibition of proliferation against of synovial cells, gene expression of inflammatory mediators such as TNF-$\alpha$, IL-1$\beta$ and IL-6, DNA-binding activity of $NF-_{k}B$ and AP-1 were measured in vitro. Results : CS didn't show cytotoxicity against human synovial cells and inhibited proliferation of human synovial cells in a dose-dependent manner in combination with rIL-6. CS reduced the gene expression of IL-6 and IL-1$\beta$ in a dose- dependent manner but didn't reduced that of TNF-$\alpha$ in human synovial cells. CS reduced the binding-activity of $NF-_{k}B$ and also reduced that of AP-1 remarkably. Conclusion: We found out that Cordyceps sinensis has immunomodulatory effect of suppressing synovial cells. And Cordyceps sinensis will be used as a stable remedium in the auto-immune disease in the future.

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