A Case of Paragonimiasis that was Suspicious for a Lung Malignancy by PET/CT

PET/CT에서 폐암으로 의심된 폐흡충증 1예

  • Moon, You Ri (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Lee, Yang Deok (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Park, Sang Hyun (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Cho, Yong Soo (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Na, Dong Jib (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Cho, Yong Seon (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Han, Min Soo (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Choi, Hee Jeong (Department of Family Medicine, Eulji University School of Medicine) ;
  • Kim, Do Hyung (Department of Thoracic Surgery, Eulji University School of Medicine) ;
  • Yang, Seoung Oh (Department of Radiology, Eulji University School of Medicine) ;
  • Kim, Kyung Hee (Department of Pathology, Eulji University School of Medicine)
  • 문유리 (을지대학교 의과대학 내과학교실) ;
  • 이양덕 (을지대학교 의과대학 내과학교실) ;
  • 박상현 (을지대학교 의과대학 내과학교실) ;
  • 조용수 (을지대학교 의과대학 내과학교실) ;
  • 나동집 (을지대학교 의과대학 내과학교실) ;
  • 조용선 (을지대학교 의과대학 내과학교실) ;
  • 한민수 (을지대학교 의과대학 내과학교실) ;
  • 최희정 (을지대학교 의과대학 가정의학교실) ;
  • 김도형 (을지대학교 의과대학 흉부외과학교실) ;
  • 양승오 (을지대학교 의과대학 영상의학교실) ;
  • 김경희 (을지대학교 의과대학 병리학교실)
  • Received : 2007.08.31
  • Accepted : 2007.09.29
  • Published : 2007.12.30

Abstract

Positron emission tomography/computed tomography (PET/CT) is valuable for the diagnosis of malignancies. However, PET/CT is unable to discriminate exactly between inflammation and a neoplasm. We report a case of a 50-year-old man with pulmonary paragonimiasis that was suspicious for lung cancer, as detected by PET/CT. The use of PET/CT revealed multilobulated consolidation on the right lung and patchy consolidation on the left lung, with increased fluorodeoxyglucose (FDG) uptake. In addition, the left paraaortic lymph node (LN) and peripancreatic LN showed enlargement with increased FDG uptake. Lung cancer with multiple lymph node metastases was suspected from the increased standardized uptake values (SUV>4.5) determined by PET/CT. We performed wedge resection via video-assisted thoracic surgery (VATS) and found Paragonimus westermani eggs in the involved tissues.

FDG-PET/CT는 악성종양 발견에 많은 기여를 하고 있는 영상진단법이지만, 염증성 질환에서 위양성을 보일 수 있다. 저자들은 국내외적으로 보고된 바가 많지 않은 PET/CT에서 양쪽 폐, 복부 림프절과 왼쪽 궁둥이의 증가된 FDG 섭취로 폐암으로 의심된 폐흡충증을 경험하였기에 문헌고찰과 함께 보고한다.

Keywords

References

  1. Lee SH, Chae JI, Hong ST. Synopsis of medical parasitology. 1st ed. Seoul: Korea Medical Book Publishing Co; 1996
  2. Choi JW, Park IS, Shin DH, Park SS, Lee JH. Clinical study of pulmonary paragonimiasis. Tuberc Respir Dis 1993;40:274-82
  3. Gould MK, Maclean CC, Kuschner WG, Rydzak CE, Owens DK. Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions. JAMA 2001;285:914-24 https://doi.org/10.1001/jama.285.7.914
  4. Patz EF Jr, Lowe VJ, Hoffman JM, Paine SS, Burrowes P, Coleman RE, et al. Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. Radiology 1993;188:487-90 https://doi.org/10.1148/radiology.188.2.8327702
  5. Patz EF Jr, Goodman PC. Positron emission tomography imaging of the thorax. Radiol Clin North Am 1994;32:811-23
  6. Chang JM, Lee HJ, Goo JM, Lee HY, Lee JJ, Chung JK, et al. False positive and false negative FDG-PET scans in various thoracic diseases. Korean J Radiol 2006;7: 57-69 https://doi.org/10.3348/kjr.2006.7.1.57
  7. Yoo IeR, Park HJ, Hyun J, Chung YA, Sohn HS, Chung SK, et al. Two cases of pulmonary paragonimiasis on FDG-PET CT imaging. Ann Nucl Med 2006;20:311-5 https://doi.org/10.1007/BF02984648
  8. Watanabe S, Nakamura Y, Kariatsumari K, Nagata T, Sakata R, Zinnouchi S, et al. Pulmonary paragonimiasis mimicking lung cancer on FDG-PET imaging. Anticancer Res 2003;23:3437-40
  9. Goo JM, Im JG, Do KH, Yeo JS, Seo JB, Kim HY, et al. Pulmonary tuberculoma evaluated by means of FDG-PET: findings in 10 cases. Radiology 2000;216: 117-21 https://doi.org/10.1148/radiology.216.1.r00jl19117
  10. Wilkinson MD, Fulham MJ, McCaughan BC, Constable CJ. Invasive aspergillosis mimicking stage IIIA nonsmall- cell lung cancer on FDG positron emission tomography. Clin Nucl Med 2003;28:234-52 https://doi.org/10.1097/00003072-200303000-00017
  11. Beggs AD, Hain SF. F-18 FDG-positron emission tomographic scanning and Wegener's granulomatosis. Clin Nucl Med 2002;27:705-6 https://doi.org/10.1097/00003072-200210000-00004
  12. Mukae H, Taniguchi H, Matsumoto N, Iiboshi H, Ashitani J, Matsukura S, et al. Clinicoradiologic features of pleuropulmonary Paragonimus westermani on Kyusyu Island, Japan. Chest 2001;120:514-20 https://doi.org/10.1378/chest.120.2.514
  13. DeFrain M, Hooker R. North American paragonimiasis, case report of a severe clinical infection. Chest 2002; 121:1368-72 https://doi.org/10.1378/chest.121.4.1368