Development and Reproduction (한국발생생물학회지:발생과생식)
- Volume 11 Issue 3
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- Pages.179-185
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- 2007
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- 2465-9525(pISSN)
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- 2465-9541(eISSN)
Effects of Estradiol-$17{\beta}$ and Nonylphenol on mRNA Expression of Estrogen Receptor-related Receptor $\beta$ Like 1 and Early Embryogensis in Sea Urchin, Strongylocentrotus nudus
Estradiol-$17{\beta}$ 와 Nonylphenol이 둥근성게(Strongylocentrotus nudus) 초기 배발생과 Estrogen Receptor-related Receptor $\beta$ Like 1 mRNA 발현에 미치는 영향
- Jung, Yu-Jung (Dept. of Marine Bioscience and Technology, Kangnung National University Graduate School) ;
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Maeng, Se-Joeng
(Dept. of Marine Bioscience and Technology, Kangnung National University Graduate School) ;
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Sohn, Young-Chang
(Dept. of Marine Bioscience and Technology, Kangnung National University Graduate School)
- Published : 2007.12.30
Abstract
The estrogens and estrogenic endocrine disrupting chemicals(EDCs) function through a steroid nuclear receptor-mediated process and subsequently regulate the transcription of mRNA for a number of target proteins. The estrogen receptor-related receptors(ERRs), which are structurally similar to estrogen receptors, are members of orphan nuclear receptor in the nuclear receptor superfamily and their functions are known to be involved in the formation of extra-embryonic ectoderm. To investigate effects of EDCs on early embryogenesis and ERR gene expression in marine invertebrates, we examined morphological changes and the mRNA expression of
Estrogen과 estrogenic endocrine disrupting chemicals(EDCs)는 주로 스테로이드 수용체와 작용하여 다양한 표적 단백질 유전자의 전사를 조절한다. 구조적으로 estrogen 수용체와 유사한 estrogen 수용체형 수용체(estrogen receptorrelated receptor, ERR)는 포유동물에서 배발생 후기에 외배엽 형성과 관련되어 있다고 알려진 고아핵수용체(orphan nuclear receptor)이다. 본 연구에서는 해양무척추동물인 둥근성게(Strongylocentrotus nudus)의 발생배를 재료로 estradiol-
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