Signet Ring Cell Type Gastric Adenocarcinoma in a Jindo dog

진도견에서 반지세포형 위선암종 증례보고

  • Jee, Hyang (College of Veferinary Medicine, Seoul National University) ;
  • Kang, Min-Soo (College of Veferinary Medicine, Seoul National University) ;
  • Seo, Kyoung-Won (College of Veferinary Medicine, Seoul National University) ;
  • Hwang, Cheol-Yong (College of Veferinary Medicine, Seoul National University) ;
  • Youn, Hwa-Young (College of Veferinary Medicine, Seoul National University) ;
  • Kim, Wan-Hee (College of Veferinary Medicine, Seoul National University) ;
  • Kim, Dae-Yong (College of Veferinary Medicine, Seoul National University)
  • 지향 (서울대학교 수의과대학) ;
  • 강민수 (서울대학교 수의과대학) ;
  • 서경원 (서울대학교 수의과대학) ;
  • 황철용 (서울대학교 수의과대학) ;
  • 윤화영 (서울대학교 수의과대학) ;
  • 김완희 (서울대학교 수의과대학) ;
  • 김대용 (서울대학교 수의과대학)
  • Published : 2007.06.30

Abstract

A case of gastric adenocarcinoma signet ring cell type was described in a ten-year-old female Jindo dog having about three months history of vomiting, anorexia and weight loss. On radiology, ultrasonography and computed tomography, thickness of the gastric fundus was irregularly increased. On necropsy, the gastric fundus was markedly thickened and gastric rugae were attenuated. The cardia and distal esophagus were also thickened. On histopathology, the mucosa was obliterated by neoplastic proliferation of round to polyhedral cells. The neoplastic cells had abundant vacuolated cytoplasm containing mucin. The neoplasm was infiltrated into the submucosa and muscle layer. Metastatic focus was not observed.

Keywords

References

  1. Happe RP, Van der Gaag I, Wolvekamp WT, Van Toorenburg J. Multiple polyps of the gastric mucosa in two dogs. J Small Anim Pract 1977; 18: 179-189 https://doi.org/10.1111/j.1748-5827.1977.tb05869.x
  2. Hayden DW, Fleischman RW. Scirrhous eosinophilic gastritis in dogs with gastric arteritis. Vet Pathol 1977; 14: 441-448 https://doi.org/10.1177/030098587701400503
  3. Head KW, Else RW, Dubielzig RR. Tumors of the alimentary tract. In: Tumors in domestic animals, 4th ed. Ames: Iowa State Press. 2002: 451-461
  4. Jones TC, Hunt RD, King NW. The digestive system. In: Veterinary pathology, 6th ed. Baltimore: Lippincott Williams & Wilkins. 1997: 1066-1067
  5. Kurihara M, Shirakabe H, Murakami T, Yasui A, Izumi T. A new method for producing adenocarcinomas in the stomach of dogs with N-ethyl-N'-nitro-N-nitrosoguanidine. Gann 1974; 65: 163-177
  6. Leblanc B, Fox JG, Le Net JL, Masson MT, Picard A. Hyperplastic gastritis with intraepithelia1 Campylobacter-like organisms in a Bealge dog. Vet Pathol 1993; 30: 391-394 https://doi.org/10.1177/030098589303000413
  7. Merchant JL. Inflammation, atrophy, gastric cancer: connecting the molecular dots. Gastroenterology 2005; 129: 1079-1082 https://doi.org/10.1053/j.gastro.2005.07.038
  8. Patnaik AK, Hurvitz AI, Johnson GF. Canine gastrointestinal neoplasms. Vet Pathol 1977; 14: 547-555 https://doi.org/10.1177/030098587701400602
  9. Skirrow MB. Diseases due to Campylobacter, Helicobacter and related bacteria. J Comp Pathol 1994; 111: 113-149 https://doi.org/10.1016/S0021-9975(05)80046-5
  10. Sullivan M, Lee R, Fisher EW, Nash AS, McCandlish AP. A study of 31 cases of gastric carcinoma in dogs. Vet Rec 1987; 120: 79-83 https://doi.org/10.1136/vr.120.4.79
  11. Wang FI, Lee JJ, Liu CH, Pang VF, Chang PH, Jeng CR. Scirrhous gastric carcinoma with mediastinal invasion in a dog. J Vet Diagn Invest 2002; 14: 65-68 https://doi.org/10.1177/104063870201400114
  12. Wright RP. Malignant gastric ulcer associated with adenocarcinoma ofthe gastric fundus in a dog. Vet Med Small Anim Clin 1981; 76: 845-848