대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)
- 제20권1호
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- Pages.32-49
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- 2007
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
익기양영탕(益氣養榮湯)의 항산화 및 유방암 세포주 생장 억제 효과에 미치는 영향
Antioxidative and Anti-proliferative Effects on MCF-7 Human Breast Cancer Cells of Ikiyangyoung-Tang
- Park, Kyung-Mi (Dept. of Oriental OB & GY, College of Oriental Medicine, DongShin University) ;
- Cho, Seong-Hee (Dept. of Oriental OB & GY, College of Oriental Medicine, DongShin University) ;
- Lee, Jin-A (Dept. of Oriental OB & GY, College of Oriental Medicine, DongShin University)
- 발행 : 2007.02.28
초록
Purpose: Breast cancer is the most common disease in Korean women. Despite remarkable improvements in treatment strategies against various cancer during the past 40 years, breast cancer still remains as one of the main causes of cancer mortality among women in the whole world. This study was carried out to investigate antioxidative and anti-proliferative effects on MCF-7 human breast cancer cells of Ikiyangyoung-Tang extract. Methods: We measured a content of polyphenol and flavonoid in the Ikiyangyoung-Tang extract, eliminative ability of DPPH radical, ABTS free radical and hydrogen peroxide, antioxidative effects of linoleic acid, cytotoxicity on MCF-7 human breast cancer cells. MCF-7 cells were cultured in Dulbecco's modified Eagle's medium/F12(DMEM/F12) supplemented with 10 % fetal bovine serum(FBS; Gibco) and antibiotics. Results : The extract of Ikiyangyoung-Tang contains polyphenol of 168.3
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