DOI QR코드

DOI QR Code

B16/F10 생쥐 흑색종 세포에서 제주조릿대 추출물의 멜라닌 합성 저해 효과

The inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells by Sasa quelpaertensis leaf extract

  • 윤훈석 (제주대학교 지역기술혁신센터 및 제주대학교 생명과학과, 고려대학교 생명과학과) ;
  • 김정국 (고려대학교 생명과학과) ;
  • 김세재 (제주대학교 지역기술혁신센터 및 제주대학교 생명과학과)
  • Yoon, Hoon-Seok (Technology innovation Center for Life Sciences and Department of Life Science, Cheju National University, Department of Life Sciences, School of Life Science and Biotechnology, Korea University) ;
  • Kim, Jeong-Kook (Department of Life Sciences, School of Life Science and Biotechnology, Korea University) ;
  • Kim, Se-Jae (Technology innovation Center for Life Sciences and Department of Life Science, Cheju National University)
  • 발행 : 2007.06.25

초록

Effects of hot-water extract from Sasa quelpaertensis leaf (HWES) on melanogenesis were investigated in B16/F10 mouse melanoma cells. HWES inhibited cellular tyrosinase activity and melanin biosynthesis in a dose-dependent manner. Western blotting analysis showed that HWES dose-dependently inhibited tyrosinase and tyrosinase related protein-1 expression. Also, HWES suppressed sustained ERK activation in a concentration-dependent manner, suggesting that HWES inhibits the melanin biosynthesis through the suppressive effect against pathway involving sustained ERK activation.

키워드

참고문헌

  1. Briganti, S., E. Camera and M. Picardo. 2003. Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Res. 16, 101-110 https://doi.org/10.1034/j.1600-0749.2003.00029.x
  2. Cabanes, J., S. Chazarra and F. Garcia-Carmona. 1994. Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46, 982-985 https://doi.org/10.1111/j.2042-7158.1994.tb03253.x
  3. del Marmol, V. and F. Beermann. 1996. Tyrosinase and related protein in mammalian pigmentation. FEBS Lett. 381, 165-168 https://doi.org/10.1016/0014-5793(96)00109-3
  4. Gilchrest, B. A., H. Y. Park, M. S. Eller and M. Yaar. 1996. Mechanisms of ultraviolet light-induced pigmentation. Photochem. Photobiol. 63, 1-10 https://doi.org/10.1111/j.1751-1097.1996.tb02988.x
  5. Grabbe, J., P. Welker, E. Dippel and B. M. Czarnetzki. 1994. Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes. Arch. Dermatol. Res. 287, 78-84 https://doi.org/10.1007/BF00370723
  6. Han, R., H. P. Baden, J. L. Brissette and L. Weiner. 2002. Redefining the skin's pigmentary system with a novel tyrosinase assay. Pigment Cell Res. 15, 290-297 https://doi.org/10.1034/j.1600-0749.2002.02027.x
  7. Hill, H. Z., W. Li, P. Xin and D. L. Michell. 1997. Melanin: a two edged sword? Pigment Cell Res. 10, 158-161 https://doi.org/10.1111/j.1600-0749.1997.tb00478.x
  8. Imokawa, G., T. Kobayashi, M. Miyagishi, K. Higashi and Y. Yada. 1997. The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis. Pigment Cell Res. 10, 218-228 https://doi.org/10.1111/j.1600-0749.1997.tb00488.x
  9. Im, S., E. S. Lee, W. Kim, W. On, J. Kim, M. Lee and W. H. Kang. 2002. Donor specific response of estrogen and progesterone on cultured human melanocyte. J. Korea Med. Sci. 17, 58-64 https://doi.org/10.3346/jkms.2002.17.1.58
  10. Kobayashi, T., G. Imokawa, D. C. Bennett and V. J. Hearing. 1998. Tyrosinase stabilization by Tyrp1 (the brown locus protein). J. Biol. Chem. 273, 31801-31805 https://doi.org/10.1074/jbc.273.48.31801
  11. Korner, A. and J. Pawelek. 1982. Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin. Science 217, 1163-1165 https://doi.org/10.1126/science.6810464
  12. Lee, Y. H., S. S. Park, S. W. Lee, S. H. Lee, K. H. Park, Y. J. Choi and S. W. Gal. 2006. Whitening effect of mycelial culture broth of Paecilomyces japonica in the mixture of cucumber and grape extracts. J. Life Sci. 16, 870-875 https://doi.org/10.5352/JLS.2006.16.5.870
  13. Manga, P., K. Sato, L. Ye, F. Beermann, M. L. Lamoreux and S. J. Orlow. 2000. Mutational analysis of the modulation of tyrosinase by tyrosinase-related protein 1 and 2 in vitro. Pigment Cell Res. 13, 364-374 https://doi.org/10.1034/j.1600-0749.2000.130510.x
  14. Martinez-Liarte, J. H., F. Solano, J. C. Garcia-Borron, J. R. Jara and J. A. Lozano. 1992. Alpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome tautomerase in B16/F10 mouse melanoma cells. J. Invest. Dermatol. 99, 435-439 https://doi.org/10.1111/1523-1747.ep12616139
  15. Park, J. H., Y. G. Shin, S. K. Baek, U. K. Lee, H. Chung and Y. I. Park. 1998. Tyrosinase inhibition activity of some herbal drugs. Yakhak Hoeji. 41, 518-523
  16. Romero-Graillet, C., E. Aberdam, M. Clement, J. P. Ortonne and R. Bailotti. 1997. Nitric oxide produced by ultraviolet-irradiated stimulates melanogenesis. J. Clin. Invest. 99, 635-642 https://doi.org/10.1172/JCI119206
  17. Thody, A. J. and A. Graham. 1998. Does alpha-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Res. 11, 265-274 https://doi.org/10.1111/j.1600-0749.1998.tb00735.x
  18. Tripathi, R. K., V. J. Hearing, K. Urabe, P. Aroca and R. A. Spritz. 1992. Mutational mapping of the catalytic activities of human tyrosinase. J. Biol. Chem. 267, 23707-23712
  19. Tsukamoto, K., I. J. Jackson, K. Urabe, P. M. Montague and V. J. Hearing. 1992. A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPA chrome tautomerase. EMBO J. 11, 519-526

피인용 문헌

  1. Apoptotic Effect of Sasa quelpaertensis Nakai in Human Colon Cancer HT-29 Cells vol.24, pp.9, 2014, https://doi.org/10.5352/JLS.2014.24.9.1012
  2. Whitening Effect of Extracts and Fractions from Diospyros kaki calyx vol.23, pp.3, 2013, https://doi.org/10.5352/JLS.2013.23.3.383
  3. Hypopigmenting Effects of Extracts from Bulbs of Lilium Oriental Hybrid 'Siberia' in Murine B16/F10 Melanoma Cells vol.43, pp.5, 2014, https://doi.org/10.3746/jkfn.2014.43.5.705
  4. Comparative Depigmentation Effects of Resveratrol and Its Two Methyl Analogues in α-Melanocyte Stimulating Hormone-Triggered B16/F10 Murine Melanoma Cells vol.21, pp.2, 2016, https://doi.org/10.3746/pnf.2016.21.2.155
  5. p-Coumaric acid, a constituent ofSasa quelpaertensisNakai, inhibits cellular melanogenesis stimulated by -melanocyte stimulating hormone vol.159, pp.2, 2008, https://doi.org/10.1111/j.1365-2133.2008.08653.x
  6. Effects of Hizikia fusiforme Fractions on Melanin Synthesis in B16F10 Melanoma Cells vol.23, pp.12, 2013, https://doi.org/10.5352/JLS.2013.23.12.1495