The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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The Experimental Effects of Pomegranate on the Cerebral Blood Flow and Obesity in Rats

석류가 뇌혈류 및 비만에 미치는 실험적 효과

  • Published : 2007.06.30
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Abstract

To examine the effects of pomegranate on cerebral blood flow and obesity, we observed regional cerebral blood flow in normal rats, as well as body weight, serum total cholesterol, serum HDL-cholesterol, serum LDL-cholesterol, serum triglycerides, serum total lipids, serum phospholipids and serum free fatty acid levels in rats fed a high fat diet. The results were as follows. Pomegranate seed extract significantly increased regional cerebral blood flow and the peel extract increased regional the cerebral blood flow in a dose dependent manner. In addition, the pomegranate extracts(seed, peel, juice) decreased body weight, serum total cholesterol, serum LDL-cholesterol, serum triglycerides, serum total lipids, serum phospholipids and serum free fatty acid levels, and increased serum HDL-cholesterol in the rats fed a high fat diet. More specially the seed extract significantly decreased serum total cholesterol, serum triglycerides and serum phospholipid levels.

Keywords

References

  1. Aviram, M and Dornfeld, L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158:195-198. 2002 https://doi.org/10.1016/S0021-9150(01)00412-9
  2. Gharzouli, K, Khennouf, S, Amire, S and Gharzouli, A. Effects of aqueous extracts from Quercus liex L. root bark, Punica granatum L. fruit peel and Artemisia herba-alba Asso leaves on ethanol-induced gastric damage in rats. Phytother Res. 13:42-45. 1999 https://doi.org/10.1002/(SICI)1099-1573(199902)13:1<42::AID-PTR383>3.0.CO;2-2
  3. Gil, MI, Tomas-Barberan, FA, Hess-Pierce, B, Holcroft, DM and Kader, AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem. 48:4581-4589. 2000 https://doi.org/10.1021/jf000404a
  4. Jafri, MA, Aslam, M, Javed, K and Singh, S. Effects of Punica granatum Linn.(flowers) on blood glucose level in normal and alloxan-induced diabetic rats. J. Ethnopharmacol 70:309-314. 2000 https://doi.org/10.1016/S0378-8741(99)00170-1
  5. Suzuki, R, Noguchi, R, Ota, T, Abe, M, Miyashita, K and Kawada, T. Cytotoxic effect of conjugated trienoic fatty acids on mouce tumor and human monocytic leukemia cells. Lipids. 36:477-482. 2001 https://doi.org/10.1007/s11745-001-0746-0
  6. Aviram, M, Dornfeld, L, Rosenblat, M, VoIkova, N, Kaplan, M, Coleman, R, Hayek, T, Presser, D and Fuhrman, B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation; studies in humans and in atherosclerotic apoliprotein E-deficient mice. Am J. Clin. Nutr. 71:1062-1076. 2000 https://doi.org/10.1093/ajcn/71.5.1062
  7. http://en.wikipedia.org/wiki/Pomegranate
  8. http://www.samna.co.kr/abcd/koa15.htm
  9. Jeon, BG, Jeong, HW, Lee, JR and Ji, JM The development of functional beverage the inner skin of the chesnut Castanea crenata - Physiological effects of chestnut inner skin tea, brown rice-green tea and Cassia toratea in mouse and rat-. Kor. J. Food & Nutr. 13:411-418. 2000
  10. Jeong, HW, Park, CH and Jeon, BG. The development of functional beverage from the inner skin of the chestnut Castanea crenata. - Effects on the regional cerebral blood flow, mean arterial blood pressure, proliferation of thymocytes -. Kor. J. Food & Nutr. 14:397-404. 2001
  11. Chen, ST, Hsu, CY, Hogan, EL, Maricque, H and Balentine, JD. A model of focal ischemic stoke in the rat ; reproducible extension cortical infarction. Stroke. 17:738-743. 1986 https://doi.org/10.1161/01.STR.17.4.738
  12. Richmond, W, Preparation and properities of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem. 19:1350-1356. 1973
  13. Roseschiau, P, Bernt, E and Gruber, WJ. Enzymatic determination of total cholesterol in serum. Clin. Chem. Bichem. 12:225. 1974
  14. Allain, CC, Poon, LS, Chan, CSG, Richmond, W and Fu, PC. Enzymatic determination of total serum cholesterol. Clin. Chem. 20:470. 1974
  15. Trinder, P. Determination of glucose in blood using glucose oxidase with an alternative oxyger acceptor. Ann. Clin. Bichem. 6:24-27. 1969 https://doi.org/10.1177/000456326900600108
  16. Cleeman, Jl and Lenfant, C. National cholesterol education program; progress and prospects, JAMA. 280:2099-2104. 1998 https://doi.org/10.1001/jama.280.24.2099
  17. Sugiuchi, H, Uji, Y, Okabe, H, Irie, T, Uekama, K, Kayahara, N and Miyauchi, K. Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycolmodified enzymes and sulfated alpha-cyclodextrin. Clin. Chem. 41:717-723, 1995
  18. Harris, N, Galpchian, V and Rifia, N. Three routine methods for measuring high-density lipoprotein cholesterol compared with the reference method. Clin. Chem. 42:738-743, 1996
  19. Tietz, NW. Clinical Guide to Laboratory tests, 3rd Edition. pp. 334-337, WB Saunders Company. Philadelphia PA. 1995
  20. Fossati, P and Prencipe, L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 28:2077-2080, 1982
  21. 金井泉, 金井正光: 임상검사법제요, 개정 제30판, pp.564-567, 1384-1386, 고문사, 서울. 한국. 1993
  22. Frings, CS and Dunn, RT. A colorimetric method for determination of total serum lipids based on the sulfo-phos-pho-vanillin reaction, Am. J Clin. Path. 53:89-91, 1970 https://doi.org/10.1093/ajcp/53.1.89
  23. Snedecor, GH and Cocharn, WG. Statistical Methods, 6th ed. Amos. Iowastate Univ, 1967
  24. The Korean Society of Pathology. pp.1263-1264. Pathology, Seoul, KoMun Co. 1994
  25. Lee, KE and Kim, KH. Relationship between changes of biogenic amines and free radicals in the ischemia/reperfusion injury of rat brain. J Kor. Neurological Assoc. 11:329-340. 1993
  26. Min, HK. Endocrinology, pp.104-105. Korea Medicine Co. Seoul. Korea. 1999
  27. Chai, YH, Kim, BS, Kim, KH and Park, HJ. A Study on the relationship obesity index and examination results among visitors of a comprehensive health screening center in Pusan. J Kor. Public Health Assoc. 19:64-77. 1993
  28. Kim, HJ, Kim, CH and Lim, KC. The relationship between serum cholesterol level and diatary pattern. J. Kor. Acad. Fam. Med. 17:861-868. 1996
  29. Kook, SR, Park, YS, Ko, YK and Kim, SM. Relationship of body fat, lipid, blood pressure, glucose in serum to waist-hip ratio between obese and normal body mass index group. J. Kor. Acad. Fam. Med. 18:317-327. 1997
  30. Kim, EK, Choi, JH and Kim, MK. A study on serum lipid levels and dietary fat and fatty acid intakes in primary school children. Kor. J Nutr. 31: 166-178. 1998
  31. Park, HS, Kang, YJ and Shin, ES. Serum lipid profiles and diet patterns in obese children in Seoul. J. Kor. Society for the Study of Obesity. 3:47-54. 1994
  32. Her, YR and Lim, HS. Effects of increasing dietary fat on plasma lipoprotein in young Korean women. Kor J. Nutr. 28:697-705. 1995
  33. Ross, EA, Thomas, AW, Susan, JB, Renee, AV and Ruth, SW. Relation of weight loss to change in serum lipids and lipoproteins in obese women. Am. J. Chin. Nutr. 62:350-357. 1995 https://doi.org/10.1093/ajcn/62.2.350
  34. Choue, RW, Hong, YJ, Lee, HW and Lee, SL. Effects of nutrition education in weight managment program. J. Kor. Society for the Study of Obesity. 4:23-32. 1995