Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Activity of the Fruit Extract of Gardenia jasminoides on Monoamine Oxidase

치자추출물의 Monoamine Oxidase 저해활성

  • 박태규 (건국대학교 바이오식의약연구센터) ;
  • 황금희 (건국대학교 바이오식의약연구센터)
  • Published : 2007.06.30
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Abstract

We examined the inhibitory activities against monoamine oxidase (MAO) of Gardenia jasminoides in vitro and in vivo methods. Methanolic extract and ethylacetate fraction of Gardenia jasminoides fruit showed a significant inhibitory activity on MAO-A and MAO-B in vitro. The IC$_{50}$ values of each fraction on MAO-A and MAO-B are as fo11owed; total methanol extracts 1.23 and 1.34 mg/ml, EtOAc fraction 0.72 and 0.77 mg/ml. Water-soluble fraction also showed IC$_{50}$ values of 0.81 mg/ml on MAO-B. MAO-A activity was increased by the oral administration of ethanolic extract of G. jasminoides, while MAO-B activity was decreased. The concentration of serotonin of brain tissue administrated of ethanolic extract of G. jasminoides is slightly increased in rat. This tendency is not different from the activity of deprenyl which is a well known MAO inhibitor was used as a positive control. Consequently, we suggest that G. jasminoides may have the effects on the inhibitory activity against MAO This activity of G. jasminoides is considerable for development of functional materials for treatment and control of depression, dementia, Parkinson' disease, stress and promoting exercise, etc.

Keywords

References

  1. Hwang, K.H., Kim, I.R. and Han, Y.N. (1999) Effects of cold and hot drugs on the activity of monoamine oxidase. Kor. J. Pharmacogn. 30: 145-150
  2. Hwang, K.H. and Lim, S.H. (2003) Studies on monoamine oxidase inhibitory activities of Korean medicinal plants classified to cold drugs by the theory of KIMI. Food Sci. Biotechnol. 12: 238-241
  3. Kang, B.S. (2000) Bonchohak, 6th edition, Young Lim Sa. Seoul, Korea
  4. Miura, T., Nishiyama, Y., Ichimaru, M., Moriyasu, M. and Kato, A. (1996) Hypoglycemic activity and structure-activity relationship of iridoidal glycosides. Biol Pharm Bull. 19: 160-161 https://doi.org/10.1248/bpb.19.160
  5. Peng, C.H., Huang, C.N. and Wang, C.J. (2005) The antitumor effect and mechanisms of action of penta-acetyl geniposide. Curr Cancer Drug Targets. 5: 299-305 https://doi.org/10.2174/1568009054064633
  6. Koo, H.J., Lee, S., Shin, K.H., Kim, B.C., Lim, C.J. and Park, E.H. (2004) Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Med. 70:467-469 https://doi.org/10.1055/s-2004-818978
  7. Suzuki, Y., Kondo, K., Ikeda, Y. and Umemura, K. (2001) Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 67: 807-810 https://doi.org/10.1055/s-2001-18842
  8. Pham, T.Q., Cormier, F., Farnworth, E., Tong, V.H. and Van Calsteren, M.R. (2000) Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. J. Agric. Food Chem. 48: 1455-1461 https://doi.org/10.1021/jf991263j
  9. Namba, T. (1993) The Encyclopedia of Wakan-Yaku with Color Pictures Vol. 1. Hoikusha, Osaka, Japan. 68-71
  10. Youdim, M.B., Finberg, J.P. and Tipton, K.F. (1988) Handbook of Experimental Pharmacology. 90: 119-192
  11. Sambamoorthi, U., Olfson, M., Walkup, J.T. and Crystal, S. (2003) Diffusion of new generation antidepressant treatment among elderly diagnosed with depression. Med Care. 41: 180-194 https://doi.org/10.1097/00005650-200301000-00019
  12. Laux, G., Philipp, M. and Kohnen, R. (1996) Hypertension with moclobemide. Lancet. 347: 1330
  13. Silberstein, S.D. (2001) Migraine: preventive treatment. Curr Med Res Opin. 17 Suppl. 1: s87-93 https://doi.org/10.1185/0300799039117007
  14. Danisi, F. (2002) Parkinson's disease. Therapeutic strategies to improve patient function and quality of life. Geriatrics. 57: 46-50
  15. Ahlskog, J.E. (2003) Slowing Parkinson's disease progression: recent dopamine agonist trials. Neurology. 60: 381-389 https://doi.org/10.1212/01.WNL.0000044047.58984.2F
  16. Sterling, J., Herzig, Y., Goren, T., Finkelstein, N., Lerner, D., Goldenberg, W., Miskolczi, I., Molnar, S., Rantal, F., Tamas, T., Toth, G., Zagyva, A., Zekany, A., Lavian, G., Gross, A., Friedman, R., Razin, M., Huang, W., Krais, B., Chorev, M., Youdim, M.B. and Weinstock, M. (2002) Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem. 45: 5260-5279 https://doi.org/10.1021/jm020120c
  17. SAS Institute, Inc. (1990) SAS User's Guide. Statistical Analysis Systems Institute, Cary, NC, U.S.A
  18. Daniel, M.B. and Stuart J.E. (1990) Protein Methods. Wiley- Liss, N.Y. U.S.A
  19. Hwang, K.H., Ma, J.Y. and Kim, I.R. (1999) The studies on the theory of KIMI by the activity of monoamine oxidase. Korean J. Herbology 14: 1-14
  20. Hwang, K.H., Ma, J.Y. and Kim, I.R. (1998) The studies on the theory of KIMI of symptoms by the activity of monoamine oxidase. J. of The Association for Neo Medicine 3: 65-74
  21. Liu, B.S., Yao, C.H., Hsu, S.H., Yeh, T.S., Chen, Y.S. and Kao, S.T. (2004) A novel use of genipin-fixed gelatin as extracellular matrix for peripheral nerve regeneration. J. Biomater Appl. 19: 21-34 https://doi.org/10.1177/0885328204042544
  22. Suzuki, Y., Kondo, K., Ikeda, Y. and Umemura, K. (2001) Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 67: 807-810 https://doi.org/10.1055/s-2001-18842