YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Sesquiterpene Lactones from Saussurea lappa and Their Cell Proliferation Effects on Human Breast Cell Lines

목향(木香)으로부터 분리된 Sesquiterpene 화합물의 암세포 생육저해에 대한 활성

  • Park, Hyun-Sun (Plant Resources Research Institute, Duksung Women's University) ;
  • Choi, Eun-Jeong (Plant Resources Research Institute, Duksung Women's University) ;
  • Lee, Yong-Soo (Plant Resources Research Institute, Duksung Women's University) ;
  • Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
  • 박현선 (덕성여자대학교 식물자원연구소) ;
  • 최은정 (덕성여자대학교 식물자원연구소) ;
  • 이용수 (덕성여자대학교 식물자원연구소) ;
  • 김건희 (덕성여자대학교 식물자원연구소)
  • Published : 2007.04.30
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Abstract

Saussurea Radix, the dried roots of Saussurea lappa Clark (Compositae), has been used in oriental traditional medicine for aromatic stomachic. Present study was carried out for the anticancer effect of Saussurea Radix. Bioassay-directed fractionation of Saussurea Radix led to the isolation of two sesquiterpenes, dehydrocostuslactone (1) and costunolide (2). The structures of 1 and 2 were elucidated by spectral methods (MS, IR, $^1$H and $^{13}$C NMR). These compounds showed a potent cell proliferation activity against human breast cancer cell MCF-7 and MDA-MB-453.

Keywords

References

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