Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Immunomodulatory Effect of Aqueous Extracted Zingiberis Rhizoma on Cyclophosphamide - Induced Immune Suppression

건강 열수추출액이 Cyclophosphamide에 의해 유도된 면역억제조절에 미치는 영향

  • Lee, Young-Sun (Department of Traditional Health Resource Development, College of Sung Duk) ;
  • Lee, Geum-Hong (Department Pathology, College of Oriental Medicine, Deagu Haany University) ;
  • Kwon, Young-Kyu (Department Physiology, College of Oriental Medicine, Deage Haany University) ;
  • Park, Jong-Hyun (Department Pathology, College of Oriental Medicine, Deagu Haany University) ;
  • Shin, Sang-Woo (Department Pathology, College of Oriental Medicine, Deagu Haany University)
  • 이영선 (성덕대학 전통건강자원개발과) ;
  • 이금홍 (대구한의대학교 한의과대학 병리학교실) ;
  • 권영규 (대구한의대학교 한의과대학 생리학교실) ;
  • 박종현 (대구한의대학교 한의과대학 병리학교실) ;
  • 신상우 (대구한의대학교 한의과대학 병리학교실)
  • Published : 2007.04.25
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Abstract

Zingiberis rhizoma(ZB) has been used to treat a various condition and disease in many traditional preparation. The present study was conducted to investigate the immunomodulatory effect on cyclophosphamide(CY)-induced immunotoxicity of aqueous-extracted ZB(ZBE) using in vitro and in vivo experiment. In vitro experiment, the mouse spleen cells proliferation and nitric oxide(NO) production in RAW 264.7 mouse macrophage cells were investigated. ZBE enhanced mitogenic activity in mouse spleen cells. The suppression of CY-induced mouse speen cell proliferation was significantly restored by ZBE treatment. ZBE inhibited NO production, iNOS mRNA and protein levels in LPS-stimulated RAW 264.7 cells. In vivo experiment, ZBE was orally administrated(single dose of 150mg/kg for 12 days) and CY i.p(150mg/kg) injected to SD rats. In CY alone injected group, body weights and spleen weights, and a various hematological parameters were reduced when compared with control group, whereas those values were increased by concomitant treatment of CY and ZBE when compared with CY alone injected group. These results indicated that ZBE can modulate CY-induced immune suppression through immune cell proliferation, the regulation of NO production and the inhibition of CY-induced immunotoxicity.

Keywords

References

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