동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권3호
  • /
  • Pages.714-720
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  • 2007
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

비허온습방(脾虛蘊濕方)이 NC/Nga 아토피피부염 생쥐 모델의 피부 및 면역학적 변화에 미치는 영향

Suppression of DNCB-induced Dermatitis in NC/Nga Murine Model by Biheoonsupbang

  • 김정환 (대전대학교 한의과대학 병리학교실) ;
  • 최정준 (대전대학교 한의과대학 병리학교실) ;
  • 구영선 (대전대학교 한의과대학 내과학교실) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Kim, Jung-Hwan (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Choi, Jeong-June (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Koo, Young-Sun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Roh, Seong-Soo (Laboratory of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)
  • 발행 : 2007.06.25
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초록

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by inflammatory cell infiltration in the skin. This study was performed to assess the therapeutic effects of BHOSB on the DNCB-induced dermatitis in NC/Nga mice, characterized by the onset of AD along with an increase the number of inflammatory cells and dysregulation of inflammatory mediators including cytokines and chemokines. BHOSB administration significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. Histological findings indicated that the thickening of epidermis/dermis and dermal infiltration of inflammatory cells including mast cells were dramatically reduced. The suppression of dermatitis by BHOSB was accompanied by a decrease in the number of CD11b$^+$/Gr-1$^+$ immune cells in skin but not CD3$^+$/CCR3$^+$ cells. However, the number of CD3$^+$ cells was increased in BHOSB administrated NC/Nga mice. Oral administration of BHOSB significantly reduced the level of IL-6, TNF-a and eotaxin 2 mRNA in skin. These data suggest that BHOSB may be effective therapeutic agents for the treatment of AD.

키워드

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