The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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A Study on the Melanin Synthesis Inhibition and Whitening Effect of Schizandrae Fructus

오미자(五味子)의 멜라닌 생성 억제와 미백효과에 관한 연구

  • 두인선 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 임규상 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 황충연 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 박민철 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 김남권 (원광대학교 한의과대학 안이비인후피부과학교실)
  • Published : 2007.12.25
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Abstract

Objective : The aim of this study is to assess the effect of Schizandrae Fructus on melanin synthesis inhibition and whitening effect. Methods : We assessed inhibitory effects of Schizandrae Fructus on melanin-release from B16F10, on melanin production in B16F10, on mushroom tyrosinase activity in vitro, on tyrosinase activity in B16F10 and effect of Schizandrae Fructus on the expression tyrosinase, TRP-1, TRP-2, PKA, ERK-1 ERK-2, AKT-1, MITF in B16F10. Results and Conclusion : 1. Schizandrae Fructus inhibited melanin-release, melanin production in B16F10. 2. Schizandrae Fructus inhibited tyrosinase activity in vitro and in B16F10. 3. Schizandrae Fructus suppressed the expression of tyrosinase, TRP-1, TRP-2, PKA, ERK-2 in B16F10.

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