The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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A Study on the Melanin Synthesis Inhibition and Whitening Effect of Bombysis Corpus

백강잠의 멜라닌 생성 억제와 미백효과에 관한 연구

  • 오한철 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 임규상 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 황충연 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 윤인환 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 김남권 (원광대학교 한의과대학 안이비인후피부과학교실)
  • Published : 2007.12.25
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Abstract

Objective : This study was performed to assess the whitening effect of Bombysis Corpus on melanin synthesis. Methods : The whitening effects of Bombysis Corpus were examined by in vitro melanin production assay. We assessed inhibitory effects of Bombysis Corpus on melanin-release from B16F10, on melanin production in B16F10, on mushroom tyrosinase activity in vitro, on tyrosinase activity in B16F10, effect of Bombysis Corpus on the expression tyrosinase, TRP-1, PKA, ERK-1 ERK-2, AKT-1, MITF in B16F10. Results : 1. Bombysis Corpus inhibited melanin-release, melanin production in B16F10. 2. Bombysis Corpus inhibited tyrosinase activity in vitro and in B16F10. 3. Bombysis Corpus suppressed the expression of tyrosinase, TRP-1 in B16F10. 4. Bombysis Corpus suppressed the expression of PKA in B16F10. 5. Bombysis Corpus suppressed the expression of ERK-1, ERK-2, AKT-1 in B16F10. 6. Bombysis Corpus suppressed the expression of MITF in B16F10. Conclusion : The study shows that Bombysis Corpus inhibited melanin production on the melanogenesis.

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