Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Clinical Study on Matrix Metalloprotease-l Gene Polymorphism in Korean Facial Nerve Palsy Patients

구안와사(口眼渦斜) 환자(患者)의 Matrix Metalloprotease-l (MMP-l)의 유전자(遺傳子) 다형성(多形性)에 대한 연구(硏究)

  • Choi, Sung-Hun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Kyung-Min (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Bong-Hyo (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University) ;
  • Lim, Seong-Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University) ;
  • Jung, Tae-Young (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University) ;
  • Seo, Jung-Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University)
  • 최성훈 (대구한의대학교 한의과대학 침구경혈학교실) ;
  • 이경민 (대구한의대학교 한의과대학 침구경혈학교실) ;
  • 이봉효 (대구한의대학교 한의과대학 침구경혈학교실) ;
  • 임성철 (대구한의대학교 한의과대학 침구경혈학교실) ;
  • 정태영 (대구한의대학교 한의과대학 침구경혈학교실) ;
  • 서정철 (대구한의대학교 한의과대학 침구경혈학교실)
  • Published : 2007.04.20
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Abstract

Objectives : This study was designed to investigate the relation between the matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. Methods : This study was carried out on 102 facial nerve palsy patients who were treated with oriental medicine therapy at the department of acupuncture & moxibustion, hospital of Oriental medical college, Daegu Hanny University and 104 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. We have investigated the genotyping of matrix metalloprotease-1 by using Pyrosequencing. Results : The genotypes of matrix metalloprotease-l gene were G/G homozygotes, A/G heterozygotes and A/A homozygotes. There was no significant difference between the control and facial nerve palsy groups. Conclusion: We concluded that there was no significant association between matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies.

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