대한의생명과학회지 (Biomedical Science Letters)
- 제13권2호
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- Pages.157-160
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Up-regulation of Early Growth Response-1 Expression by Endoplasmic Reticulum Stress
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권오유
(충남대학교 의과대학 해부학교실)
- Han, Song-Yi (Department of Anatomy, College of Medicine, Chungnam National University) ;
- Kwon, Ki-Sang (Department of Anatomy, College of Medicine, Chungnam National University) ;
- Yun, Eun-Young (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
- Goo, Tae-Won (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
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Kwon, O-Yu
(Department of Anatomy, College of Medicine, Chungnam National University)
- 발행 : 2007.06.30
초록
Endoplasmic reticulum (ER) plays formation of disulfide bonds and proper folding of secretory proteins. Cellular responses to ER stress enhances the stress-activated kinase pathway and the induces a lot of immediate-early genes. Among of them, the early growth response-1 (Egr-1), a transcription factor, which plays an important role in cell growth, development, differentiation, apoptosis and various types of injury. For that reason, we have tested the expression of Egr-1 against ER stress inducible drugs (tunicamycin, DTT, A23187 and BFA) to understand what kind of aspect occurred by ER stresses.
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