대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
권호 표지

결합조직형성소원형세포종양의 압착도말 세포학적 소견 -1예 보고-

Imprint Cytology of a Desmoplastic Small Round Cell Tumor -A Case Report-

  • 김용진 (영남대학교의과대학 병리과) ;
  • 김재황 (영남대학교의과대학 외과) ;
  • 최준혁 (영남대학교의과대학 병리과)
  • Kim, Yong-Jin (Department of Pathology, Yeungnam University College of Medicine) ;
  • Kim, Jae-Hwang (Department of Sugery, Yeungnam University College of Medicine) ;
  • Choi, Joon-Hyuk (Department of Pathology, Yeungnam University College of Medicine)
  • 발행 : 2007.03.30
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초록

Desmoplastic small round cell tumor (DSRCT) is a rare malignant mesenchymal neoplasm. It mainly involves the abdominal or pelvic peritoneum of male adolescents. We report here the imprint cytologic features of a case of DSRCT occurring in the intraabdominal cavity of a 21-year-old man. A microscopic examination showed moderate cellularity. The tumor cells were singly arranged and arranged in clusters. The cells had round to oval nuclei with finely granular chromatin, inconspicuous nucleoli and scanty cytoplasm. Some tumor cells showed nuclear molding, and some cells had an epitheloid appearance with a large amount of lightly eosinophilic cytoplasm. A rosette-like pattern was present. Spindle-shaped, fibroblastic stromal cells were occasionally found. The tumor cells were immunoreactive for the markers cytokeratin (AE1/AE3), epithelial membrane antigen (EMA), desmin, vimentin and neuron specific enolase (NSE).

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참고문헌

  1. Antonescu CR, Gerald W. Desmoplastic small round cell tumour. In : Fletcher CDM, Unni K, Mertens F: WHO classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARCPress, 2002;216-8
  2. Gerald WL, Rosai J. Case 2. Desmoplastic small cell tumor with divergent differentiation. Pediatr Pathol 1989;9:177-83 https://doi.org/10.3109/15513818909022347
  3. Setrakian S, Gupta PK, Heald J, Brooks JJ. Intraabdominal desmoplastic small round cell tumour. Report of a case diagnosed by fine needle aspiration cytology. Acta Cytol 1992;36:373-6
  4. Caraway NP, Fanning CV, Amato RJ, Ordonez NG, Katz RL. Fine needle aspiration of intra-abdominal desmoplastic small round cell tumor. Diagn Cytopathol 1993;9:465-70 https://doi.org/10.1002/dc.2840090419
  5. Akhtar M, Ali MA, Sabbah R, Bakry M, Al-Dayel F. Small round cell tumour with divergent differentiation: cytological, histologic, and ultrastructural findings. Diagn Cytopathol 1994;11:159-64 https://doi.org/10.1002/dc.2840110210
  6. El-Kattan I, Redline RW, El-Naggar AK, Grimes MC, Abdul- Karim FW. Cytologic features of intraabdominal desmoplastic small round cell tumor. A case report. Acta Cytol 1995;39;514-20
  7. Logrono R, Kurtycz DF, Sproat IA, Allan RW, Inhorn SL. Diagnosis of recurrent desmoplastic small round cell tumor by fine needle aspiration. A case report. Acta Cytol 1997;41:1402-6 https://doi.org/10.1159/000333549
  8. Ali SZ, Nicol T, Port J, Ford G. Intraabdominal desmoplastic small round cell tumour: cytopathologic findings in two cases. Diagn Cytopathol 1998;18:449-52 https://doi.org/10.1002/(SICI)1097-0339(199806)18:6<449::AID-DC13>3.0.CO;2-H
  9. Insabato L, Di Vizio D, Lambertini M, Bucci L, Pettinato G. Fine needle aspiration cytology of desmoplastic small round cell tumor. A case report. Acta Cytol 1999;43:641-6 https://doi.org/10.1159/000331159
  10. Ferlicot S, Coue O, Gilbert E, et al. Intraabdominal desmoplastic small round cell tumor: report of a case with fine needle aspiration, cytologic diagnosis and molecular confirmation. Acta Cytol 2001;45:617-21 https://doi.org/10.1159/000327875
  11. Dave B, Shet T, Chinoy R. Desmoplastic round cell tumor of childhood: can cytology with immunocytochemistry serve as an alternative for tissue diagnosis? Diagn Cytopathol 2005;32:330-5 https://doi.org/10.1002/dc.20244
  12. Lae ME, Roche PC, Jin L, Lloyd RV, Nascimento AG. Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical, and molecular study of 32 tumors. Am J Surg Pathol 2002;26:823-35 https://doi.org/10.1097/00000478-200207000-00001
  13. Ordonez NG. Desmoplastic small round cell tumor: II: an ultrastructural and immunohistochemical study with emphasis on new immunohistochemical markers. Am J Surg Pathol 1998;22:1314-27 https://doi.org/10.1097/00000478-199811000-00002
  14. Gerald WL, Miller HK, Battifora H, Miettinen M, Silva EG, Rosai J. Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of highgrade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol 1991;15:499-513 https://doi.org/10.1097/00000478-199106000-00001
  15. Biegel JA, Conard K, Brooks JJ. Translocation (11;22) (p13;q12): primary change in intra-abdominal desmoplastic small round cell tumor. Genes Chromosomes Cancer 1993;7:119-21 https://doi.org/10.1002/gcc.2870070210
  16. Gerald WL, Haber DA. The EWS-WT1 gene fusion in desmoplastic small round cell tumor. Semin Cancer Biol 2005;15:197-205 https://doi.org/10.1016/j.semcancer.2005.01.005
  17. Silverman JF, Joshi VV. FNA biopsy of small round cell tumors of childhood: cytomorphologic features and the role of ancillary studies. Diagn Cytopathol 1994;10:245-55 https://doi.org/10.1002/dc.2840100312
  18. Akhtar M, Iqbal MA, Mourad W, Ali MA. Fine-needle aspiration biopsy diagnosis of small round cell tumors of childhood: a comprehensive approach. Diagn Cytopathol 1999;21:81-91 https://doi.org/10.1002/(SICI)1097-0339(199908)21:2<81::AID-DC2>3.0.CO;2-A
  19. Kempson RL, Fletcher CD, Evans HL, Hendrickson MR, Sibley RK. Atlas of tumor pathology. Tumors of the soft tissues. 3rd series. Fascicle 30. Washington, D.C.: Armed Forces Institute of Pathology, 2001;452-8
  20. Choi JK, van Hoeven K, Brooks JJ, Gupta PK. Desmoplastic small round cell tumor presenting in pleural fluid and accompanied by desmin-positive mesothelial cells. Acta Cytol 1995;39:377-8
  21. Hassan I, Shyyan R, Donohue JH, et al. Intraabdominal desmoplastic small round cell tumors: a diagnostic and therapeutic challenge. Cancer 2005;104:1264-70 https://doi.org/10.1002/cncr.21282