Pediatric Gastroenterology, Hepatology & Nutrition
- Volume 10 Issue 2
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- Pages.117-128
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- 2007
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- 2234-8646(pISSN)
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- 2234-8840(eISSN)
Food Protein-induced Enterocolitis Syndrome: an Update on Clinical Approaches and Its Pathophysiology
식품 단백질 유발성 장염 증후군: 임상적 접근과 병태생리의 최신 지견
- Hwang, Jin-Bok (Department of Pediatrics, Keimyung University School of Medicine)
- 황진복 (계명대학교 의과대학 소아과학교실)
- Received : 2007.07.31
- Accepted : 2007.08.24
- Published : 2007.09.30
Abstract
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated hypersensitivity disorder, which is associated with mainly gastrointestinal symptoms and has a delayed onset. The vomiting and/or diarrheal symptoms of FPIES typically begin in the first month of life in association with a failure to thrive, metabolic acidosis, and shock. Therefore, the differential diagnosis of FPIES and neonatal or infantile sepsis-like illnesses or gastroenteritis is difficult. The early recognition of indexes of suspicion for FPIES may help in the diagnosis and treatment of this disorder. The diagnosis of FPIES is generally made through clinical practice and food-specific IgE test findings are typically negative in this condition. Therefore, oral cow's milk challenge (OCC) remains the valid diagnostic standard for FPIES. An investigation of positive OCC outcomes helps to find out a diagnostic algorithm of criteria of a positive challenge in FPIES. Moreover, it has not been clearly determined in infantile FPIES when
Keywords
- Food protein-induced enterocolitis syndrome;
- Food allergy;
- Oral food challenge;
- Follow up;
- Enteropathy;
- Apoptosis