Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Acute Myeloid Leukemia with t(8;21)(q22;q22) (AML1/ETO) in a Patient with Marked Hypocellularity and Low Blasts Count

  • Chun, Sung-Ho (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Cho, Hee-Soon (Department of Laboratory Medicine, College of Medicine, Yeungnam University) ;
  • Lee, Chae-Hoon (Department of Laboratory Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Kyung-Dong (Department of Laboratory Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Min-Kyoung (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Hyun, Myung-Soo (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Jung, Soon-Il (Department of Internal Medicine, College of Medicine, Yeungnam University)
  • ;
  • 조희순 (영남대학교 의과대학 진단검사의학과학교실) ;
  • ;
  • ;
  • ;
  • ;
  • Published : 2007.06.30
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Abstract

According to the World Health Organization (WHO) classification system, cases with t(8;21)(q22;q22) should be diagnosed as acute myeloid leukemia (AML) even with a blast count of less than 20 percent in blood or bone marrow. It is an uncommon manifestation, moreover hypocellularity is rarely observed in this subtype of leukemia. Here, we report a case of t(8;21) in a patient with marked hypocellularity of less than 5 percent and a blast count of less than 20 percent. This patient responded relatively well to chemotherapy. An allogeneic bone marrow transplantation was performed with good engraftment. This case suggests that hypocellular AML with a t(8;21) has as good a prognosis as hypercellular AML with t(8;21).

세계보건기구의 분류에 따르면 8번 염색체와 21번 염색체의 전위인 t(8;21)(q22;q22)를 가진 경우는 말초혈액이나 골수에 모세포가 20% 미만이더라도 급성골수성백혈병으로 분류하여야 하며, 이는 흔하지 않은 소견이다. 뿐만 아니라 이런 아형의 백혈병에서 골수의 저세포 충실도는 매두 드물다. 저자들은 골수세포충실도가 5% 미만으로 심하게 감소되어 있고, 골수의 모세포도 20% 미만인 환자에서 t(8;21)을 관찰하여 급성골수성백혈병으로 진단한 1례를 보고하는 바이다. 항암치료에 잘 반응하고 동종골수이식의 생착이 잘 이루어져, t(8;21)을 가진 일반적인 고세포충실성 급성골수성백혈병과 유사하게 좋은 예후를 가지는 것으로 생각된다.

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