Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Redoxcitrinin, a Biogenetic Precursor of Citrinin from Marine Isolate of Fungus Penicillium sp.

  • Zhang, Dahai (College of Chemistry & Chemical Engineering, Ocean University of China) ;
  • Li, Xianguo (College of Chemistry & Chemical Engineering, Ocean University of China) ;
  • Kang, Jung-Sook (College of Dentistry, Pusan National University) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Jung, Jee-H. (College of Pharmacy, Pusan National University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Published : 2007.05.31
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Abstract

A chemical analysis of the fermentation of the marine-derived fungus Penicillium sp. led to the isolation of a biogenetic precursor of citrinin, redoxcitrinin(1), together with polyketide mycotoxins, phenol A(2), citrinin H2(3), 4-hydroxymellein(4), citrinin(5), and phenol A acid(6). The structures of compounds 1-6 were determined on the basis of physicochemical data analyses. Among them, compounds 1-3 exhibited a potent radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl(DPPH) with $IC_{50}$ values of 27.7, 23.4, and $27.2{\mu}M$, respectively.

Keywords

References

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