Biomolecules & Therapeutics

  • 제15권1호
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  • Pages.46-51
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  • 2007
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Isolation and Antioxidative Activities of Caffeoylquinic Acid Derivatives and Flavonoid Glycosides from Leaves of Sweet Potato (Ipomoea batatas L.)

  • Kim, Hyoung-Ja (Bioanalysis and Biotransformation Research Center, Division of Life Sciences, Korea Institute of Science & Technology, Kyung Hee East-West Pharmaceutical Research Institute and Department of Life and Nanopharmaceutical Sciences, College of Phamacy, Kyung Hee University) ;
  • Jin, Chang-Bae (Bioanalysis and Biotransformation Research Center, Division of Life Sciences, Korea Institute of Science & Technology) ;
  • Lee, Yong-Sup (Kyung Hee East-West Pharmaceutical Research Institute and Department of Life and Nanopharmaceutical Sciences, College of Phamacy, Kyung Hee University)
  • 발행 : 2007.03.30
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초록

Bioassay-directed chromatographic fractionation of an ethyl acetate extract from leaves of sweet potato (Ipomoea batatas L.) afforded six quinic acid derivatives: 3,5-epi-dicaffeoylquinic acid (1), 3,5-dicaffeoylquinic acid (2), methyl 3,5-O-dicaffeoylquinate (3), methyl 3,4-dicaffeoylquinate (4), methyl 4,5-dicaffeoylquinic acid (5),4,5-dicaffeoylquinate (6), and two phenolic compounds: caffeic acid (7) and caffeic acid methyl ester (8) together with three flavonoids: quercetin 3-O-${\beta}$-D-glucopyranoside (9), quercetin 3-O-${\beta}$-D-glucopyranoside, isoquercitrin (10) and kaempferol 3-O-${\beta}$-D-glucopyranoside (11). The structures of these compounds were elucidated by the aid of spectroscopic methods. These compounds were assessed for antioxidant activities using three different cell-free bioassay systems. All isolates except 11 showed potent DPPH and superoxide anion radicals scavenging, and lipid peroxidation inhibitory activities. 3,5-epi-DCQA (1) and methyl quinates (3-5) along with flavonoide 9 were isolated for the first time from this plant.

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