Natural Product Sciences

  • 제13권1호
  • /
  • Pages.6-10
  • /
  • 2007
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Analgesic and Anti-inflammatory Activity of Carissa carandas Linn fruits and Microstylis wallichii Lindl Tubers

  • Reddy, G.D. (Ethno pharmacology and Pharmacognosy Division, N.B.R.I.) ;
  • Kaushik, Atul (Formulation and Development Section, Ranbaxy Laboratories) ;
  • Shanker, K. (Drug Standardisation Research Unit, C.R.I.) ;
  • Tiwari, R.K. (Drug Standardisation Research Unit, C.R.I.) ;
  • Mukherjee, Alok (Dept. of Pharmacy, Allahabad Agriculture Institute-Deemed University) ;
  • Rao, Ch.V. (Ethno pharmacology and Pharmacognosy Division, N.B.R.I.) ;
  • Sharma, Alok (Ethno pharmacology and Pharmacognosy Division, N.B.R.I.)
  • 발행 : 2007.03.31
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초록

The ethanolic (50% v/v) extracts of Carissa carandas (fruits) (Apocynaceae) and Microstylis wallichii (tubers) (Orchidaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. Carissa carandas and Microstylis wallichii (50-200 mg/kg) caused a dose dependent inhibition of swelling caused by carrageenin significantly in cotton pellet induced granuloma in rats (P < 0.05 to P < 0.001). There was a significant increase in the analgesy meter induced pain in rats. The extracts of Carissa carandas and Microstylis wallichii resulted in an inhibition of stretching episodes and percentage protection was 16.05-17.58%respectively in acetic acid induced writhing.

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