Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cancer Chemopreventive Activity of the Rhizome Extract of Alpinia officinarum

고양강 추출물의 암예방 활성

  • Ku, Kang-Mo (College of Agricultural and Life Science, Kyungpook National University) ;
  • Chang, Young-Jin (College of Agricultural and Life Science, Kyungpook National University) ;
  • Kim, Min-Gun (College of Agricultural and Life Science, Kyungpook National University) ;
  • Kim, Kil-Ung (College of Agricultural and Life Science, Kyungpook National University) ;
  • Song, Kyung-Sik (College of Agricultural and Life Science, Kyungpook National University) ;
  • Kang, Young-Hwa (College of Agricultural and Life Science, Kyungpook National University)
  • 구강모 (경북대학교 농업생명과학대학 응용생명과학부) ;
  • 장영진 (경북대학교 농업생명과학대학 응용생명과학부) ;
  • 김민근 (경북대학교 농업생명과학대학 응용생명과학부) ;
  • 김길웅 (경북대학교 농업생명과학대학 응용생명과학부) ;
  • 송경식 (경북대학교 농업생명과학대학 응용생명과학부) ;
  • 강영화 (경북대학교 농업생명과학대학 응용생명과학부)
  • Published : 2007.03.31
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Abstract

In order to find novel cancer chemopreventive agents, quinone reductase (QR) inductive activity of methanol extract of herbal medicines was examined using murine hepatoma, hepa1c1c7 cells. QR has been used as an anticarcinogenic marker enzyme in cancer chemoprevention study. The methanol extract of Alpinia officinarum (Zingiberace) showed showed significantly strong quinone reductase inductive activity compared to the control group. The methanol extract of Alpinia officinarum was successively fractionated with various solvents according to polarity. Hexane, ethyl acetate, buthanol and water fractions were obtained and theirs activities were assessed. The QR inductive effect was moved to the ethyl acetate fraction and was highly increased. The CD (concentration required to double the specific activity of QR) value of ethyl acetate fraction was 8.6 ${\mu}g/mL$. Alpinia officinarum also showed strong antioxidant activity. These results suggest that Alpinia officinarum can be developed as cancer chemopreventive agent.

Keywords

References

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