Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Activity on Monoamine Oxidase of Chrysanthemum indicum L.

감국의 Monoamine Oxidase 저해활성

  • Chang, Eun-Ju (Bio-Food and Drug Research Center, Konkuk University) ;
  • Choi, Dong-Kug (Bio-Food and Drug Research Center, Konkuk University) ;
  • Park, Tae-Kyu (Bio-Food and Drug Research Center, Konkuk University) ;
  • Hwang, Keum-Hee (Bio-Food and Drug Research Center, Konkuk University)
  • 장은주 (건국대학교 바이오식의약연구센터) ;
  • 최동국 (건국대학교 바이오식의약연구센터) ;
  • 박태규 (건국대학교 바이오식의약연구센터) ;
  • 황금희 (건국대학교 바이오식의약연구센터)
  • Published : 2007.03.31
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Abstract

We examined the inhibitory activities against monoamine oxidase (MAO) of Chrysanthemum indicum L. in vitro and in vivo methods. Methanolic extract of C. indicum showed significant inhibitory activities on MAO-A that were prepared from rat brain in vitro. The inhibitory activities were measured by serotonin as a substrate. The $IC_{50}$ value of methanolic extract of C. indicum was 0.24 mg/ml for the inhibition of MAO-A. The ethylacetate fraction of methanolic extract of C. indicum exhibited the best activity toward MAO-A with $IC_{50}$ value of 0.05 mg/ml in vitro. It was observed that those activities in vivo tests have different tendency each other. Ethanolic extract of C. indicum was have no effect on rat MAO by the oral administration (p<0.05). However, MAO inhibitory activities of ethanolic extract of C. indicum by the oral administration have similar tendency to those of iproniazid. Consequently, we suggest that C. indicum may have the effects on the inhibitory activities against MAO both in vitro and in vivo. These results indicates that the C. indicum extract has properties indicative of potential neuroprotective ability.

Keywords

References

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