Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Estimation of Visual Stimulus Intensity From Retinal Ganglion Cell Spike Trains Using Optimal Linear Filter

최적선형필터를 이용한 망막신경절세포 Spike Train으로부터의 시각자극 세기 변화 추정

  • Ryu, Sang-Baek (Department of Biomedical Engineering, College of Health Science and Yonsei Medical Engineering Institute, Yonsei University) ;
  • Kim, Doo-Hee (Department of Biomedical Engineering, College of Health Science and Yonsei Medical Engineering Institute, Yonsei University) ;
  • Ye, Jang-Hee (Department of Physiology, Chungbuk National University Medical School) ;
  • Kim, Kyung-Hwan (Department of Biomedical Engineering, College of Health Science and Yonsei Medical Engineering Institute, Yonsei University) ;
  • Goo, Yong-Sook (Department of Physiology, Chungbuk National University Medical School)
  • 류상백 (연세대학교 보건과학대학 의공학과, 연세의료공학연구원) ;
  • 김두희 (연세대학교 보건과학대학 의공학과, 연세의료공학연구원) ;
  • 예장희 (충북대학교 의과대학 생리학교실) ;
  • 김경환 (연세대학교 보건과학대학 의공학과, 연세의료공학연구원) ;
  • 구용숙 (충북대학교 의과대학 생리학교실)
  • Published : 2007.04.30
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Abstract

As a preliminary study for the development of electrical stimulation strategy of artificial retina, we set up a method fur the reconstruction of input intensity variation from retinal ganglion cell(RGC) responses. In order to estimate light intensity variation, we used an optimal linear filter trained from given stimulus intensity variation and multiple single unit spike trains from RGCs. By applying ON/OFF stimulation(ON duration: 2 sec, OFF duration: 5 sec) repetitively, we identified three functional types of ganglion cells according to when they respond to the ON/OFF stimulus actively: ON cell, OFF cell, and ON-OFF cell. Experiments were also performed using a Gaussian random stimulus and a binary random stimulus. The input intensity was updated once every 90 msec(i. e. 11 Hz) to present the stimulus. The result of reconstructing 11 Hz Gaussian and binary random stimulus was not satisfactory and showed low correlation between the original and reconstructed stimulus. In the case of ON/OFF stimulus in which temporal variation is slow, successful reconstruction was achieved and the correlation coefficient was as high as 0.8.

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