Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Cheonggi-san Inhibits Atopy Dermatitis in NC/Nga Mouse through Regulation of iNOS mRNA Expresssion & NO production

청기산(淸肌散)의 iNOS 발현과 NO 생성 억제가 NC/Nga 생쥐의 아토피 피부염에 미치는 영향

  • Ahn, Sang-Hyun (Department of Anatomy, Oriental Medicine College, Dongguk University) ;
  • Kim, Ho-Hyun (Department of Physiology, Oriental Medicine College, Semyung University) ;
  • Kim, Jin-Taek (Department of Anatomy, Oriental Medicine College, Dongguk University)
  • 안상현 (동국대학교 한의과대학 해부학교실) ;
  • 김호현 (세명대학교 한의과대학 생리학교실) ;
  • 김진택 (동국대학교 한의과대학 해부학교실)
  • Published : 2007.10.25
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Abstract

Inducible nitric oxide synthase (iNOS) are important inflammation enzyme and severe up-nitric oxide (NO) production by this enzyme has been intricate with pathogenesis of atopy dermatitis. The present study was designed in order to determine whether Cheonggi-san could inhibit atopy dermatitis through modulation of iNOS mRNA expression and NO production. We found that iNOS mRNA expression and NO production in RAW 264.7 macrophages stimulated with lipopolysaccharide dose-dependantly decreased by Cheonggi-san extract treatment (0.5 - 2.0 mg/ml). The distribution of iNOS positive reacted cell in NC/Nga mice with atopy dermatitis were decreased by Cheonggi-san extract treatment (2.5 ml/kg/day) and apoptosis were increased. These data likely indicate that Cheonggi-san may act as inflammatory regulator for atopy dermatitis and may be possible to develop useful agent for chemoprevention of NO intricate inflammatory diseases.

Keywords

References

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