Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
권호 표지

조기발병 정신분열병 환아에서 SPECT로 측정한 국소 뇌혈류량 이상 : SPM(Statistical Parametric Mapping) 분석

Regional Cerebral Perfusion Abnormalities Assessed with Brain SPECT in Early-onset Schizophrenia : Statistical Parametric Mapping Analysis

  • 조수철 (서울대학교 의과대학 정신과학교실, 소아.청소년 정신과) ;
  • 황준원 (서울대학교 의과대학 정신과학교실, 소아.청소년 정신과) ;
  • 김붕년 (서울대학교 의과대학 정신과학교실, 소아.청소년 정신과) ;
  • 김재원 (서울대학교 의과대학 정신과학교실, 소아.청소년 정신과) ;
  • 신민섭 (서울대학교 의과대학 정신과학교실, 소아.청소년 정신과) ;
  • 이동수 (서울대학교 의과대학 핵의학교실) ;
  • 이호영 (서울대학교 의과대학 핵의학교실) ;
  • 김양렬 (서울대학교 의과대학 정신과학교실) ;
  • 김효원 (서울대학교 의과대학 정신과학교실, 소아.청소년 정신과)
  • Cho, Soo-Churl (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Hwang, Jun-Won (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Kim, Boong-Nyun (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Shin, Min-Sup (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Lee, Dong-Soo (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Lee, Ho-Young (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Kim, Yang-Yeol (Department of Neuropsychiatry, Seoul National University College of Medicine) ;
  • Kim, Hyo-Won (Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine)
  • 발행 : 2007.04.30
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초록

Objectives : A voxel based investigation of cerebral blood flow was conducted to identify functional differences during resting state between children with early-onset schizophrenia and normal controls. Methods : 19 children and adolescents with early-onset schizophrenia(8 boys and 11 girls, mean age $14.0{\pm}1.7$ years old) and 17 comparison children(13 boys and 4 girls, mean age $11.0{\pm}1.9$ years old) were examined by HMPAO-SPECT. The SPECT images were compared using statistical parametric mapping analyses, controlling for age and sex. Results : Increased cerebral blood flow in left medial and inferior frontal gyrus, right superior and middle frontal gyrus, both inferior temporal gyrus, and right cerebellar tonsil was found in children and adolescents with early-onset schizophrenia compared to control subjects. In addition, decreased cerebral blood flow in right thalamus, left posterior cingulate gyrus, right anterior cingulate gyrus and relatively wide areas from left medical frontal gyrus to superior parietal lobule were found in children and adolescents with early-onset schizophrenia compared to control subjects. Conclusion : The results of the current study provide additional evidences for brain areas involving the onset of schizophrenia in early age.

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