Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Comparison of Full Genome Sequences Between Two Hepatitis B Virus Strains With or Without preC Mutation (A1896) from a Single Korean Hepatocellular Carcinoma Patient

  • Kim, Hong (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University) ;
  • Jee, Young-Mee (Department of Enteroviruses, Division of Virology, National Institute of Health) ;
  • Mun, Ho-Suk (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University) ;
  • Song, Byung-Cheol (Department of Internal Medicine, College of Medicine, Cheju National University) ;
  • Park, Joo-Hee (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University) ;
  • Hyun, Jin-Won (Department of Internal Medicine, College of Medicine, Cheju National University) ;
  • Hwang, Eung-Soo (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University) ;
  • Cha, Chang-Yong (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University) ;
  • Kook, Yoon-Hoh (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University) ;
  • Kim, Bum-Joon (Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University)
  • Published : 2007.04.30
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Abstract

This report describes the full-length sequences of 2HBV clones from a hepatocellular carcinoma (HCC) patient, one with preC mutation (1896A) and the other without preC mutation. The high level of discrepancy in mutation frequency between these 2 strains was observed in the Core (C) region among 4 ORFs. These data support previous results that Korean HBV strains, belonging to genotype C2, are prone to mutations. It is possible that the mutations (BCP and preC mutations) associated with the HBeAg defective production might contribute to the diversity of mutations related to HBV persistence, playing an important role in hepatocarcinogenesis in this patient.

Keywords

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