Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Identification of the causes of anemia and differential diagnosis of immune-mediated hemolytic anemia in anemic patient dogs

빈혈의 원인동정과 면역매개용혈성빈혈의 감별진단

  • Lee, Youn-Kyung (Veterinary College of Chonnam National University) ;
  • Lee, Chai-Yong (Veterinary College of Chonnam National University) ;
  • Nam, Hyang-Mi (National Veterinary Research and Quarantine Service, MAF) ;
  • Kang, Mun-Il (National Veterinary Research and Quarantine Service, MAF)
  • Published : 2007.03.30
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Abstract

Anemia is a common problem in sick dogs, and immune-mediated hemolytic anemia (IMHA) is one of the most common causes of anemia in dogs. Since death can occur rapidly in dogs with IMHA even with appropriate treatment, it is important to differentiate IMHA from other causes of anemia in its first stages. To diagnose underlying diseases in anemic dogs and differentiate IMHA cases from others, 29 patient dogs suffering from severe anemia that had been referred to Veterinary Medical Teaching Hospital at a National University from June 2004 to April 2005 were examined. The most common cause of anemia in the patient dogs was found to be liver disease accounting for 31.0% (9/29) of all, and the second most common was IMHA with 13.7% (4/29). Four dogs confirmed as IMHA cases all reacted positive to direct anti-globulin test and showed spherocytes and polychromatic erythrocytes in the blood smear. Most of the IMHA cases (3/4) were female aged 2 to 7 years and were in a severe state of anemia with less than 20% of PCV.

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References

  1. Betsy A. 2000. Clinical and hematologic manifestations of anemia. In: Schalm's Veterinary hematology. 5eds. Lippincott. Williams & Wilkins Co:140-142
  2. Giger U. 2005. Regenerative anemias caused by blood loss or hemolysis. In: Textbook of veterinary internal medicine, 6eds. Philadelphia. Elsevier Saunders Co:1886-1907
  3. Bennett D, Finnett SL, Nash AS, et al. 1981. Primary autoimmune haemolytic anaemia in the dog. Vet Rec 109(8):150-153 https://doi.org/10.1136/vr.109.8.150
  4. Burgess K, Moore A, Rand W, et al. 2000. Treatment of immune mediated hemolytic anemia in dogs with cyclophosphamide. J Vet Intern Med 14(4): 456-462 https://doi.org/10.1892/0891-6640(2000)014<0456:TOIHAI>2.3.CO;2
  5. McCullough S. 2003. Immune-mediated hemolytic anemia: understanding the nemesis. Vet Clin North Am Small Anim Pract 33(6):1295-1315 https://doi.org/10.1016/j.cvsm.2003.08.003
  6. Reimer ME, Troy GC, Warnick LD. 1999. Immune-mediated hemolytic anemia: 70 cases (1988-1996). J Am Anim Hosp Assoc 35(5):384-391 https://doi.org/10.5326/15473317-35-5-384
  7. Stewart AF, Feldman BF. 1993(a). Immune mediated hemolytic anemia. Part 1: an overview. Compendium on Continuing Education for the Practing Veterian. 15: 372-381
  8. Stewart AF, Feldman BF. (1993b). Immune mediated hemolytic anemia. Part II. Clinical entity, diagnosis, and treatment theory. Compendium on Continuing Education for the Practing Veterian. 15: 1479-1491
  9. Lifton SJ. Managing immune-mediated hemolytic anemia in dogs. Veterinary medicine. 1999: 532-545
  10. Andrew GA, Smith JE. 2000. Iron metabolism; In: Schalm's Veterinary hematology, 5eds. Lippincott. Willams & Wilkins Co :129-134
  11. Cynthia R Webster L. 2005. History, clinical signs and physical findings in hepatobiliary disease. In: Textbook of veterinary internal medicine. vol 2. 6eds. Elsevier Saunders:1422-1434
  12. Krantz SB. 2002. Pathogenesis and treatment of anemia of chronic disease. Blood Review : 16: 87-96 https://doi.org/10.1054/blre.2002.0193
  13. Allyn ME, Troy GC. 1997 Immune mediated hemolytic anemia, a retrospective study: focus on treatment and mortality (1988-1996). In: Proceedings of the 15th American College of Veterinary Internal Medicine Forum. Lake Buena Vista May 22,1997: 678
  14. Opdenakker G, Fibbe WE, Van Damme J. 1998. The molecular basis of leukocytosis. Immunol Today 19(4):182-189 https://doi.org/10.1016/S0167-5699(97)01243-7
  15. Warren RW, Collins ML. 1988. Immune hemolytic anemia in children. Crit Rev Oncol Hematol 8(1):65-73 https://doi.org/10.1016/S1040-8428(88)80005-2