Comparison of Cold Pack and Capsaicin Application in Temporomandibular Disorder Treatment

측두하악장애 치료에 있어 냉찜질과 capsaicin적용에 관한 비교

  • Lim, Hyun-Dae (Department of Oral medicine, College of Dentistry, Wonkwang University) ;
  • Lee, You-Mee (Department of Oral medicine, College of Dentistry, Wonkwang University)
  • 임현대 (원광대학교 치과대학 구강내과학 교실) ;
  • 이유미 (원광대학교 치과대학 구강내과학 교실)
  • Published : 2007.06.30


This investigation was carried out to evaluate the effect of pain control temporomandibular disorders with clinical application of capsaicin cream. 20 healthy subjects without systemic diseases were measured in current perception threshold and pain tolerance threshold with $Neurometer^{(R)}$ CPT/C (Neurotron, Inc. Baltimore, Maryland, USA) after cold pack, 0.025% capsaicin and 0.075% capsaicin cream application. The obtained results were as follows : 1. The current perception threshold of C-fiber was significantly higher to the baseline on. There were significantly increased in C- fiber current perception threshold of 0.025% capsaicin cream and 0.075% capsaicin cream application comparison to cold pack. 2. There was significantly increased in pain tolerance threshold of cold pack and 0.075% capsaicin application comparison to one of baseline as $A{\beta}$-fiber, There was significantly higher after cold pack and 0.025% capsaicin cream application than baseline as $A{\delta}$-fiber. In C-fiber case, 0.025% capsaicin application's was significantly increased than baseline one. 3.There were significantly higher C-fiber of 0.075% capsaicin application than baseline in visual analogue scale marking pain level of pain tolerance threshold.


  1. Sessile BJ. Peripheral and central mechanisms of orofacial pain and their clinical correlates. MINERVA ANESTESIOL 2005;71:117-136
  2. Okeson JP. Bell's orofacial pain. The clinical management of orofacial pain. 6th ed., Chicago, 2005, Quintessence Publishing Co. Inc., pp. 46-56
  3. Ostuki T, Nakahma H, Nhzuma H et al. Evaluation of the analgesic effects of capsaicin using a New Rat Model For tonic pain. Brain Research, 1986;365: 235-240
  4. Valeriani M, Tinazzi M, Le Pera D et al. Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials. Exp Brain Res 2005;160:29-37
  5. 김해영,손여원,이상섭 등. 지속성 진통작용 물질인 capsaicinoid의 흰쥐 척수내 substance P함량 및 생합 성에 미치는 영향. 한국생화학회지 1990;23(2):246-250
  6. Chado H. The current perception threshold evaluation of sensory nerve function in pain management. Pain Digest 1995;5:124-134
  7. Kim HS, Kho HS, Kim YK et al. Reliability and characteristics of current perception thresholds in the territory of the infraorbital and inferior alveolar nerves. J Orofac Pain 2000;14(4):286-292
  8. Masson EA, Veves A, Ferando D et al. Current perception threshold: A new, quick and reproducible method for the assessment of peripheral neurophathy in diabets mellitus. Diabetologia 1989;32:724-728
  9. Masson EA, Boulton AJ. The neurometer: validation and comparison with conventional test for diabetic neuropathy. Diabet Med 1991;8:63-66
  10. Carter RB. Topical capsaicin in the treatment of cutaneous disorders. Drug Development Research 1991;22:109-123
  11. Deal CL, Schnitizer TJ, Lipstein E et al. Treatment of arthritis with Topical Capsaicin: A double-blind trial. Clinical Therapeutics 1991;13(3):383-395
  12. Alper BS, Lewis PR. Treatment of postherpetic neuralgia: a systematic review of the literature. J Fam Pract 2002;51(2):121-128
  13. Christo PJ, Hobelmann G, Maine DN. Post-herpetic neuralgia in older adults: evidence-based approaches to clinical management. Drugs Aging 2007;24 (1):1-19
  14. Ghilardi JR, Röhrich H, Lindsay TH et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci 2005;25(12):3126-3131
  15. Erin N, Boyer PJ, Bonneau RH, Clawson GA et al. Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res 2004;24:1003-1009
  16. Epstein JB, Marcoe JH. Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 1994;77(2):135-140
  17. Simons CT, Boucher Y, Carstens E. Suppression of central taste transmission by oral capsaicin. J Neurosci 2003;23(3):978-985
  18. Badvari S. ed. The Merck Index. 12th ed. 1996, Merck & Co. Inc. pp. 287-288
  19. Nakagawa H, Hiura A. Capsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neurons. Anatomical Science International 2006;81:135-155
  20. Petruzzi M, Lauritano D, De Benedittis M et al. Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. J Oral Pathol Med 2004;33:111-114
  21. McMAhon SB, Lewin G, Bloom SR. The consequences of long-term topical capsaicin application in the rat. Pain 1991;44:301-310
  22. Hansen LB, Jensen TS, Svensson P. A human model of intraoral pain and heat hyperalgesia. J Orofacial Pain 2003;17:333-340
  23. Hansen LB List T, Jensen TS, Leijon G et al. Blink reflexes in patient with atypical odontalgia. J Orofacial Pain 2005;10:239-247
  24. Sommer C. Is serotonin hyperalgesic or analgesic? Current pain and headache reports 2006;10:101-106