Application of Stress Hormones in Saliva in Research of Orofacial Pain Related with Stress

스트레스와 관련된 구강안면통증의 연구에 있어서 타액내의 스트레스호르몬의 활용

  • Ryu, Ji-Won (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Yoon, Chang-Lyuk (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Ahn, Jong-Mo (Department of Oral Medicine, College of Dentistry, Chosun University)
  • 유지원 (조선대학교 치과대학 구강내과학교실) ;
  • 윤창륙 (조선대학교 치과대학 구강내과학교실) ;
  • 안종모 (조선대학교 치과대학 구강내과학교실)
  • Published : 2007.06.30

Abstract

Many diseases occur by stress or effect of stress. The basis for using hormones in research of stress is the observation that most systems in the body show changes during stress and that hormonal markers in these changes are related with stress. Conceptually, the central role of sympathetic nervous system(SNS) and hypothalamus-pituitary-adrenal(HPA) axis activity in stress provides copious justification for measuring hormonal changes. Catecholamines like epinephrine and norepinephrine, cortisol, testosterone and growth hormone and so on show sensitive reaction to stress. The major advantage of salivary sample to stress research is that its sampling technique can be performed in non-stressful conditions and without physical restraint and ethical problems. Because hormone levels in saliva is a good reflection of hormone levels in plasma, application of stress hormones in saliva is very useful for research of orofacial pain related with stress.

많은 질병들과 기존에 존재하는 신체적인 질병들은 스트레스로 인해 발병되거나 크고 작은 스트레스의 영향으로 악화된다. 스트레스의 연구에 호르몬을 사용하는 기본은 신체의 대부분 시스템이 스트레스를 받는 동안 변화를 보인다는 것과 이러한 변화에 호르몬이 스트레스와 확실하게 연관되어 있다는 것을 관찰하는 것이다. 개념적으로 스트레스에 있어서 교감신경계와 시상하부-뇌하수체-부신축의 활성화가 중심적인 역할을 한다는 것이 호르몬의 변화를 측정해야 할 충분한 근거를 제공한다. 에피네프린과 노르에피네프린과 같은 카테콜라민, 코티졸, 테스토스테론 그리고 성장호르몬 등은 스트레스에 예민한 반응을 보인다. 한편 스트레스 연구를 위한 타액표본은 혈액이나 요의 표본과는 달리 스트레스를 주지 않고도 표본을 얻을 수 있으며 신체적인 구속이나 윤리적인 문제 등을 염려하지 않고도 채취가 가능하다는 장점이 있다. 타액내의 호르몬의 수치는 혈액내의 호르몬 수치를 잘 반영하므로 스트레스와 관련된 구강안면통증의 연구에 있어서 타액내의 스트레스 호르몬에 활용도는 매우 높으리라고 사료된다.

Keywords

References

  1. 고경봉. 스트레스와 정신신체의학. 서울, 2002, 일조각, pp. 3-56
  2. Lipowski ZJ. Psychosomatic medicine and liaison psychiatry. New York, 1985, Plenum Medical Book Co., pp. 3-90
  3. Vickers RR. Effectiveness of Defenses: A significant predictor of cortisol excretion under stress. J Psychosom Res 1988;32(1):21-29 https://doi.org/10.1016/0022-3999(88)90085-2
  4. Board F, Persky H, Hamburg DA. Psychological stress and endocrine functions. Psychosom Med 1956;18(4):324-333 https://doi.org/10.1097/00006842-195607000-00006
  5. Mean JH. Lecture on the thyroid. Cambridge, 1954, Harvard
  6. Rice PL. Stress and health: Principles and practice for coping and wellness. Pacific Grove, Califonia, 1987, Brooks/Cole Publishing Co., pp. 17-60
  7. Baum A, Grunberg N. Measurement of stress hormones. In Cohen S, Kessler RC, Gordon LU (Ed). Measuring stress. New York, 1995, Oxford Univ. Press, pp. 175-192
  8. Hofman LF. Human saliva as a diagnostic specimen. J Nutr 2001; 131(5):1621-1625 https://doi.org/10.1093/jn/131.5.1621S
  9. Queyras A, Carosi M. Non-invasive techniques for analysing hormonal indicators of stress. Ann Ist Super Sanita 2004;40(2):211-221
  10. Weibel L. Methodological guideline for the use of salivary cortisol as biological marker of stress. Press Med 2003;32(18):845-851
  11. Mitome M, Shirakawa T, Kikuiri T, Oguchi H. Salivary catacholamine assay for assessing anxiety in pediatric dental patients. J Clin Pediatr Dent 1997;21(3):255-259
  12. Van Cauter E. Pulsatile ACTH secretion. In Wagner T, Filicori M (Ed). Episodic hormone secretion: From basic science to clinical application. Hameln, 1987, TM-Verlag, pp. 65-75
  13. Corenblum B. Taylor PJ. Mechanism of control of prolactin release in response to apprehension stress and anesthesia-surgery stress. Fertil Steril 1981;36: 712-715 https://doi.org/10.1016/S0015-0282(16)45912-1
  14. Hartley LH, Mason JW, Hogan RP et al. Multiple hormonal responses to graded exercise in relation to physical training. J App Physiol 1972;33:602-606 https://doi.org/10.1152/jappl.1972.33.5.602
  15. Smallridge RC, Whorton NE, Burman KD, Ferguson EW. Effect of exercise and physical fitness on the pituitary-thyroid axis and on prolactin secretion in male runners. Metabolism 1985;34:947-954
  16. Levin S. Cortisol changes following repeated experience with parachute training. In Ursin H, Baade E, Levine S (Ed). Psychobiology of Stress. New York, 1978, Academic Press
  17. Meyerhoff JL, Oleshansky MA, Mougey EH. Psychological stress increases plasma levels of prolactin, cortisol, and POMC-derived peptides in man. Psychosom Med 1988;50:295-303 https://doi.org/10.1097/00006842-198805000-00007
  18. Lehnert H, Beyer J, Walger P et al. Salivary cortisol in normal men: the effects of corticotropin-releasing factor and different psychological stimuli. In Weiner H, Florin I, Murison R, Helhammer D (Ed). Frontiers of stress Reserch. Toronto, 1989, Hans Huber, pp. 392-394
  19. Bohnen N, Nicolson N, Sulon J, Jolles J. Coping style, trait anxiety and cortisol reactivity during mental stress. J Psychosom Res 1991;35:141-147 https://doi.org/10.1016/0022-3999(91)90068-Y
  20. McCartan BE, Lamey PJ, Wallace AM. Salivary cortisol and anxiety in recurrent aphthous stomatitis. J Oral Pathol Med 1996;25(7):357-359 https://doi.org/10.1111/j.1600-0714.1996.tb00278.x
  21. Koray M, Dulger O, Ak G et al. The evaluation of anxiety and salivary cortisol levels in patients with oral lichen planus. Oral Dis 2003;9(6):298-301 https://doi.org/10.1034/j.1601-0825.2003.00960.x
  22. Rodstrom PO, Jontell M, Hakeberg M, Berggren U, Lindstedt G. Erosive oral linchen planus and salivary cortisol. J Oral Pathol Med 2001;30(5):257-263 https://doi.org/10.1034/j.1600-0714.2001.300501.x
  23. Genco RJ, Ho AW, Kopman J et al. Models to evaluate the role of stress in periodontal disease. Ann Periodontol 1998;3(1):288-302 https://doi.org/10.1902/annals.1998.3.1.288
  24. Jones DA, Rollman GB, Brooke RI. The cortisol response to psychological stress in temporomandibular dysfunction. Pain 1997;72:171-182 https://doi.org/10.1016/S0304-3959(97)00035-3
  25. Ben Aryeh H, Gottlieb I, Ish-shalom S et al. Oral complaints related to menopause. Maturitas 1996; 24(3):185-189 https://doi.org/10.1016/0378-5122(95)00988-4
  26. Bakke M, Tuxen A, Thomsen CE et al. Salivary cortisol level, salivary flow rate, and masticatory muscle activity in response to acute mental stress : a comparison between aged and young women. Gerontology 2004;50(6):383-392 https://doi.org/10.1159/000080176
  27. Whelan TL, Dishman JD, Burke J, Levine S, Sciotti V. The effect of chiropractic manipulation on salivary cortisol levels. J Manipulative Physiol Ther 2002;25(3):149-153 https://doi.org/10.1067/mmt.2002.122328
  28. Hill CM, Walker RV. Salivary cortisol determination and self-rating scales in the assessment of stress in patients undergoing the extraction of wisdom teeth. Br Dent J 2001;191(9):513-515 https://doi.org/10.1038/sj.bdj.4801220a
  29. Brand HS. Anxiety and cortisol excretion correlate prior to dental treatment. Int Dent J 1999;49(6): 330-336 https://doi.org/10.1111/j.1875-595X.1999.tb00533.x
  30. Kandemir S, Oksan T, Alpoz AR, Ergezer G, Kabalak T. Salivary cortisol levels in children during dental treatment. J Marmara Univ Dent Fac 1997;2(4): 639-642.31. Akyuz S, Pince S, Hekin N. Children's stress during a restorative dental treatment : assessment using salivary cortisol measurements. J Clin Pediatr Dent 1996;20(3):219-223
  31. Miller CS, Dembo JB, Falace DA, Kaplan AL. Salivary cortisol response to dental treatment of varying stress. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79(4):436-441 https://doi.org/10.1016/S1079-2104(05)80123-4
  32. Sachar EJ. Hormonal change in stress and mental illness. In Krieger DT, Hughes JC (Ed). Neuroendocrinology. New York, 1980, HP Publishing Co., pp. 177-183
  33. Hellhammer DH, Huber W, Schurmeyer T. Changes in saliva testosterone after psychological stimulation in men. Psychoneuroendocrinology 1985;10(1):77-81 https://doi.org/10.1016/0306-4530(85)90041-1
  34. Dabbs JM Jr. Salivary testosterone measurements in behavioral studies. Ann New York Acad Sci 1993;694:177-183 https://doi.org/10.1111/j.1749-6632.1993.tb18351.x
  35. Fukui H, Yamashita M. The effects of music and visual stress on testosterone and cortisol in men and women. Neuro Endocrinol Lett 2003;24:173-180
  36. Vienravi V, Amatayakul K, Kanluan T, Uttavichai C, Andres R. A driect radioimmunoassay for free progesterone in saliva. J Med Assoc Thai 1994; 77(3):138-147
  37. Wong YF, Mao K, Panesar NS et al. Salivary estradiol and progesterone during the normal ovulatory menstrual cycle in Chinese women. Eur J Obstet Gynecol Reprod Biol 1990;34:129-135 https://doi.org/10.1016/0028-2243(90)90016-T
  38. Choe JK, Khan-Dawood FS, Dawood MY. Progesterone and estradiol in the saliva and plasma during the menstrual cycle. Am J Obstet Gynecol 1983;147: 557-562 https://doi.org/10.1016/0002-9378(83)90016-9
  39. Ellison PT. Measurenents of salivary progesterone. Ann New York Acad Sci 1993;694:161-176 https://doi.org/10.1111/j.1749-6632.1993.tb18350.x
  40. Rantonen PJ, Penttila I, Meurman JH et al. Growth hormone and cortisol in serum and saliva. Acta Odontol Scand 2000;58(6):299-303 https://doi.org/10.1080/00016350050217163
  41. Kosten TR, Jacobs S, Mason J, Wahby V, Atkins S. Psychological correlates of growth hormon response to stress. Psychosom Med 1984;46:49-57 https://doi.org/10.1097/00006842-198401000-00007
  42. Kurokawa N, Suematsu H, Tamai H et al. Effect of emotional stress on human growth hormon secretion. J Psychosom Res 1977;21:231-235 https://doi.org/10.1016/0022-3999(77)90095-2
  43. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research : recent development and applications. Psychoneuroendocrinology 1994; 19(4):313-333 https://doi.org/10.1016/0306-4530(94)90013-2
  44. Hellhammer DH, Kirschbaum C, Belkien L. Measurement of salivary cortisol under psychological stimulation. In Hingtgen JN, Hellhammer D, Huppmann G (Ed). Advanced Method in Psychobiology. Toronto, 1987, Hogrefe, pp. 281-289
  45. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychobiological research : an overview. Neuropsychobiology 1989;22(3):150-169 https://doi.org/10.1159/000118611
  46. Garde AH, Hansen AM. Long-term stability of salivary cortisol. Scand J Clin Lab Invest 2005; 65(5):433-436 https://doi.org/10.1080/00365510510025773